lncRNAs and MYC: An Intricate Relationship.
lncRNAs and MYC: An Intricate Relationship.
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DOI：
10.3390/ijms18071497
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发表时间：
2017-07-12
影响因子：
5.6
通讯作者：
Iaccarino I
中科院分区：
文献类型：
--
作者：
Iaccarino I
长非编码 RNA (lncRNA) 正在成为基因表达网络的重要调节因子，通过影响组蛋白修饰在转录水平发挥作用，或通过控制 mRNA 稳定性和翻译在转录后水平发挥作用。在已知影响致癌转化过程的基因表达网络中，由原癌基因 MYC 控制的基因表达网络是癌症中最常失调的网络之一。在 B 细胞淋巴瘤中，MYC 基因会发生染色体重排，导致 MYC 过度表达。在许多其他癌症中，MYC 周围的区域会发生基因扩增。 MYC 表达也在蛋白质和 mRNA 稳定性水平上受到控制。影响 MYC 表达的肿瘤病变导致 MYC 转录控制的基因数量和类型发生巨大变化，具体取决于不同的启动子亲和力。肿瘤样本的转录组分析表明，在不同的癌症类型中，几种 lncRNA 受到 MYC 的差异调节，其中许多可以影响癌细胞的活力和增殖。同时，lncRNA已被证明能够在转录和转录后水平上控制MYC本身的表达。鉴于靶向 MYC 依赖性转录程序有可能达到广泛的抗癌活性，对控制 MYC 表达的复杂调节机制进行分子解析对于未来确定新的治疗策略至关重要。
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is one of the most frequently deregulated in cancer. In B-cell lymphomas, the MYC gene is subject to chromosomal rearrangements that result in MYC overexpression. In many other cancers, the region surrounding MYC is subject to gene amplification. MYC expression is also controlled at the level of protein and mRNA stability. Neoplastic lesions affecting MYC expression are responsible for a drastic change in the number and the type of genes that are transcriptionally controlled by MYC, depending on differential promoter affinities. Transcriptome profiling of tumor samples has shown that several lncRNAs can be found differentially regulated by MYC in different cancer types and many of them can influence cancer cell viability and proliferation. At the same time, lncRNAs have been shown to be able to control the expression of MYC itself, both at transcriptional and post-transcriptional levels. Given that targeting the MYC-dependent transcriptional program has the potential to reach broad anticancer activity, molecular dissection of the complex regulatory mechanisms governing MYC expression will be crucial in the future for the identification of novel therapeutic strategies.
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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