ASSOCIATION OF NUTRITIONAL STATUS WITH LUNG FUNCTION AND MORBIDITY IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS: A 36-MONTH COHORT STUDY.
ASSOCIATION OF NUTRITIONAL STATUS WITH LUNG FUNCTION AND MORBIDITY IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS: A 36-MONTH COHORT STUDY.
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DOI：
10.1590/1984-0462/;2018;36;1;00006
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Moreno YMF
中科院分区：
文献类型：
--
作者：
Hauschild DB;Rosa AF;Ventura JC;Barbosa E;Moreira EAM;Ludwig Neto N;Moreno YMF
评估儿童和青少年囊性纤维化患者36个月队列中营养状况、肺功能和发病率之间的关系。 1-15岁囊性纤维化儿童和青少年的前瞻性队列研究在基线时，根据世界卫生组织（WHO）生长图表，分别通过身高体重和年龄体重指数确定<2岁和≥2岁儿童的营养状况，并将其分类为：营养不良、营养风险和可接受;并通过第50百分位数确定。肺功能以第一秒用力呼气量（FEV 1）评价。根据感染的存在确定死亡率，根据肺部恶化确定住院时间。计算风险比和95%置信区间（95%CI），当p<0.05时具有显著性。 我们评估了38名儿童和青少年（中位年龄3.8岁）。基线时被归类为营养衰竭的患者在36个月后出现肺功能受损的RR为5.00（95%CI 1.49; 16.76）。低于第50百分位数的患者出现相同结局的RR为4.61（95%CI 0.89; 23.81）。营养状况不是该队列发病的危险因素。 营养缺乏与肺功能受损相关，但与囊性纤维化儿童和青少年的发病率无关。
To evaluate the association between nutritional status, lung function and morbidity in a 36-month cohort in children and adolescents with cystic fibrosis. Prospective cohort of children and adolescents with cystic fibrosis aged 1-15 years. At the baseline, the nutritional status was determined by weight-for-height and body mass index-for-age for children <2 years and ≥2 years, respectively, and classified as: nutritional failure, nutritional risk and acceptable; and by the 50th percentile, according to the World Health Organization (WHO) growth charts. Lung function was assessed by forced expiratory volume in one second (FEV1). Morbidity was determined by the presence of infection and hospitalization by pulmonary exacerbation. Risk ratio and 95% confidence interval (95%CI) were calculated, being significant when p<0.05. We evaluated 38 children and adolescents (median age 3.8 years). Patients that were classified as having nutritional failure at baseline had a RR of 5.00 (95%CI 1.49; 16.76) to present impaired lung function after 36 months. Those classified bellow the 50th percentile had a RR of 4.61 (95%CI 0.89; 23.81) to present the same outcome. Nutritional status was not a risk factor for morbidity in this cohort. Nutritional deficit was associated with impaired lung function, but not with morbidity in children and adolescents with cystic fibrosis.
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影响因子：
5.7
作者：
Solomon, Missale;Bozic, Molly;Mascarenhas, Maria R.
通讯作者：
Mascarenhas, Maria R.
影响因子：
10
作者：
Ranganathan, Sarath C.;Parsons, Faith;Sly, Peter D.
通讯作者：
Sly, Peter D.
影响因子：
6.3
作者：
Turck, Dominique;Braegger, Christian P.;Wilschanski, Michael
通讯作者：
Wilschanski, Michael
DOI：
10.2471/blt.07.043497
发表时间：
2007-09-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Onis, Mercedes de;Onyango, Adelheid W;Siekmann, Jonathan
通讯作者：
Siekmann, Jonathan
影响因子：
5.1
作者：
Yen, Elizabeth H.;Quinton, Hebe;Borowitz, Drucy
通讯作者：
Borowitz, Drucy