The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
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DOI：
10.1111/j.1471-4159.2010.06910.x
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发表时间：
2010-10
影响因子：
4.7
通讯作者：
Sock E
中科院分区：
文献类型：
--
作者：
Thein DC;Thalhammer JM;Hartwig AC;Crenshaw EB 3rd;Lefebvre V;Wegner M;Sock E
据报道，小鼠中枢神经系统的发育在Sox4或其近亲Sox11缺失的情况下是正常的，尽管这两种转录因子都有强而广泛的表达。在这里，我们表明，合并缺乏两个Sox蛋白在小鼠中导致严重发育不全的脊髓。脑室区神经上皮前体细胞的增殖不受影响。这些细胞也获得了正确的位置标识。神经胶质和神经元祖细胞的产生和神经元出现在一个类似的时空模式，在野生型。然而，在双缺陷脊髓的整个胚胎发生过程中，细胞死亡率急剧增加，这表明Sox4和Sox11是细胞存活共同和冗余所需的。此外，没有明显的增殖、模式化、特化和成熟缺陷表明细胞存活率降低不是这些事件之一的继发效应。因此，我们得出结论，这两个Sox蛋白直接作为促生存因子在脊髓发育的神经细胞类型。
Development of the mouse central nervous system was reported to be normal in the absence of either Sox4 or its close relative Sox11 despite strong and widespread expression of both transcription factors. Here we show that combined absence of both Sox proteins in the mouse leads to severe hypoplasia of the developing spinal cord. Proliferation of neuroepithelial precursor cells in the ventricular zone was unaffected. These cells also acquired their correct positional identity. Both glial and neuronal progenitors were generated and neurons appeared in a similar spatiotemporal pattern as in the wildtype. Rates of cell death were however dramatically increased throughout embryogenesis in the double deficient spinal cord arguing that Sox4 and Sox11 are jointly and redundantly required for cell survival. The absence of pronounced proliferation, patterning, specification, and maturation defects furthermore indicates that the decreased cell survival is not a secondary effect of one of these events. We therefore conclude that the two Sox proteins directly function as pro-survival factors during spinal cord development in neural cell types.
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DNA 损伤诱导 SOX4 对于 p53 稳定和功能至关重要
DOI：
10.1073/pnas.0810147106
发表时间：
2009-03-10
影响因子：
11.1
作者：
Pan, Xin;Zhao, Jie;Zhang, Xue-Min
通讯作者：
Zhang, Xue-Min
影响因子：
10.5
作者：
Bergsland, Maria;Werme, Martin;Muhr, Jonas
通讯作者：
Muhr, Jonas
影响因子：
4.6
作者：
Potzner, Michaela R.;Tsarovina, Konstantina;Sock, Elisabeth
通讯作者：
Sock, Elisabeth
影响因子：
6
作者：
Frierson, HF;Ei-Naggar, AK;Hampton, GM
通讯作者：
Hampton, GM
影响因子：
64.8
作者：
NOBLE, M;MURRAY, K;RIDDLE, P
通讯作者：
RIDDLE, P