Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.
Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.
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DOI：
10.3389/fimmu.2015.00175
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发表时间：
2015
影响因子：
7.3
通讯作者：
Pagani M
中科院分区：
文献类型：
--
作者：
Panzeri I;Rossetti G;Abrignani S;Pagani M
在识别外来抗原后，CD4+ naïve T淋巴细胞增殖并分化成具有不同功能的亚群。这个过程是有效免疫系统功能的基础，因为CD4+ T细胞协调先天和适应性免疫反应。传统上，这种分化事件被认为是不可逆转的细胞命运的获得，因此记忆和效应CD4+ T亚群被认为是终末分化的细胞或谱系。因此，由于它们的细胞因子和转录因子的原型集，这些谱系被传统地定义。然而，最近的研究结果表明，CD4+ T淋巴细胞具有显著的表型可塑性，因为它们经常可以根据它们遇到的环境重新指导它们的功能程序。因此，新的问题现在是引人注目的，例如哪些是可塑性和稳定性的分子决定因素，以及这两种相反力量之间的平衡如何驱动细胞的命运。如前所述，在某些情况下，细胞因子和主要调节因子的表达并不能完全解释淋巴细胞的可塑性。我们应该考虑其他层次的调控，包括表观遗传因素，如染色质状态的调节或非编码rna的转录，它们的高细胞特异性提示它们参与细胞命运的决定。在这篇综述中，我们将重点从表观遗传学的角度了解CD4+ T淋巴细胞亚群的最新进展。特别是，我们将强调非编码rna作为这些分化事件的关键参与者的重要性。我们也将在这里展示我们实验室的新数据，强调长链非编码rna在驱动人类CD4+ T淋巴细胞分化中的贡献。
Upon recognition of a foreign antigen, CD4+ naïve T lymphocytes proliferate and differentiate into subsets with distinct functions. This process is fundamental for the effective immune system function, as CD4+ T cells orchestrate both the innate and adaptive immune response. Traditionally, this differentiation event has been regarded as the acquisition of an irreversible cell fate so that memory and effector CD4+ T subsets were considered terminally differentiated cells or lineages. Consequently, these lineages are conventionally defined thanks to their prototypical set of cytokines and transcription factors. However, recent findings suggest that CD4+ T lymphocytes possess a remarkable phenotypic plasticity, as they can often re-direct their functional program depending on the milieu they encounter. Therefore, new questions are now compelling such as which are the molecular determinants underlying plasticity and stability and how the balance between these two opposite forces drives the cell fate. As already mentioned, in some cases, the mere expression of cytokines and master regulators could not fully explain lymphocytes plasticity. We should consider other layers of regulation, including epigenetic factors such as the modulation of chromatin state or the transcription of non-coding RNAs, whose high cell-specificity give a hint on their involvement in cell fate determination. In this review, we will focus on the recent advances in understanding CD4+ T lymphocytes subsets specification from an epigenetic point of view. In particular, we will emphasize the emerging importance of non-coding RNAs as key players in these differentiation events. We will also present here new data from our laboratory highlighting the contribution of long non-coding RNAs in driving human CD4+ T lymphocytes differentiation.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
64.8
作者：
Carrieri, Claudia;Cimatti, Laura;Gustincich, Stefano
通讯作者：
Gustincich, Stefano
DOI：
10.1038/nri3494
发表时间：
2013-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.