Antihypertensive medication use and incident breast cancer in women.
Antihypertensive medication use and incident breast cancer in women.
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DOI：
10.1007/s10549-015-3311-9
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发表时间：
2015-02
影响因子：
3.8
通讯作者：
Schernhammer, Eva S.
中科院分区：
文献类型：
--
作者：
Devore, Elizabeth E.;Kim, Sung;Ramin, Cody A.;Wegrzyn, Lani R.;Massa, Jennifer;Holmes, Michelle D.;Michels, Karin B.;Tamimi, Rulla M.;Forman, John P.;Schernhammer, Eva S.
为了评估抗高血压药物的使用（包括长期使用）是否与女性乳腺癌发病率增加相关，我们研究了210，641名参加护士健康研究（NHS）和护士健康研究II（NHS II）的美国注册护士。在两个队列中每两年一次的问卷调查中收集关于抗高血压药物使用的信息，并在此期间确定乳腺癌病例。使用多变量校正的考克斯比例风险模型估计随访期间（1988-2012年NHS，1989-2011年NHS II）总体抗高血压药物使用类别和特定类别（利尿剂、β受体阻滞剂、钙通道阻滞剂和血管紧张素转换酶抑制剂）使用类别中浸润性乳腺癌的相对风险。在随访期间，有10，012例浸润性乳腺癌发生（NHS中有6，718例，NHS II中有3，294例）。总体而言，与NHS（多变量校正的相对风险=1.00，95% CI=0.95 - 1.06）或NHS II（多变量校正的相对风险=0.94，95% CI =0.86 - 1.03）中既往/从未使用降压药物相比，当前使用任何降压药物与乳腺癌风险无关。此外，没有特定类别的降压药物与乳腺癌风险一致相关。当我们仅考虑高血压女性时，以及当我们评估药物使用的一致性和持续时间时，结果相似。总体而言，抗高血压药物的使用与NHS队列中女性浸润性乳腺癌的风险基本无关。
To evaluate whether antihypertensive medication use, including long-term use, is associated with increased breast cancer incidence in women We studied 210,641 U.S. registered nurses participating in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHS II). Information on antihypertensive medication use was collected on biennial questionnaires in both cohorts, and breast cancer cases were ascertained during this period. Multivariable-adjusted Cox proportional hazard models were used to estimate relative risks of invasive breast cancer over follow up (1988–2012 in NHS, 1989–2011 in NHS II) across categories of overall antihypertensive medication use and use of specific classes (diuretics, beta blockers, calcium channel blockers, and angiotensin-converting enzyme inhibitors). During follow up, 10,012 cases of invasive breast cancer developed (6,718 cases in NHS and 3,294 in the NHS II). Overall, current use of any antihypertensive medication was not associated with breast cancer risk compared with past/never use in NHS (multivariable-adjusted relative risk=1.00, 95% CI=0.95 to 1.06) or NHS II (multivariable-adjusted relative risk=0.94, 95% CI=0.86 to 1.03). Furthermore, no specific class of antihypertensive medication was consistently associated with breast cancer risk. Results were similar when we considered hypertensive women only, and when we evaluated consistency and duration of medication use over time. Overall, antihypertensive medication use was largely unrelated to the risk of invasive breast cancer among women in the NHS cohorts.
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影响因子：
8.3
作者：
Olsen, JH;Sorensen, HT;Olsen, J
通讯作者：
Olsen, J
DOI：
10.1161/hypertensionaha.110.168005
发表时间：
2011-06
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carson AP;Howard G;Burke GL;Shea S;Levitan EB;Muntner P
通讯作者：
Muntner P
影响因子：
168.9
作者：
Lever, AF;Hole, DJ;Robertson, JWK
通讯作者：
Robertson, JWK
影响因子：
6.4
作者：
Baer, Heather J.;Rich-Edwards, Janet W.;Michels, Karin B.
通讯作者：
Michels, Karin B.
影响因子：
--
作者：
Meier, CR;Derby, LE;Jick, H
通讯作者：
Jick, H