cGMP signaling pathway that modulates NF-κB activation in innate immune responses.
cGMP signaling pathway that modulates NF-κB activation in innate immune responses.
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DOI：
10.1016/j.isci.2021.103473
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发表时间：
2021-12-17
期刊：
影响因子：
5.8
通讯作者：
Kurata S
中科院分区：
文献类型：
--
作者：
Kanoh H;Iwashita S;Kuraishi T;Goto A;Fuse N;Ueno H;Nimura M;Oyama T;Tang C;Watanabe R;Hori A;Momiuchi Y;Ishikawa H;Suzuki H;Nabe K;Takagaki T;Fukuzaki M;Tong LL;Yamada S;Oshima Y;Aigaki T;Dow JAT;Davies SA;Kurata S
核因子-κ B（NF-κB）通路是一种进化上保守的信号通路，在免疫应答和炎症反应中起着重要作用。在这里，我们表明，果蝇NF-κB信号通过与Toll受体平行的途径被受体型鸟苷酸环化酶Gyc 76 C激活。Gyc 76 C产生环磷酸鸟苷（cGMP）并通过下游Toll受体组分dMyd 88、Pelle、Tube和Dif/Dorsal（NF-κB）调节NF-κB信号传导。cGMP信号通路包括称为DG 2的膜定位cGMP依赖性蛋白激酶（cGK）和蛋白磷酸酶2A（PP 2A），并且对于果蝇中宿主抵抗革兰氏阳性细菌感染的存活至关重要。膜结合cGK PRKG 2也通过PP 2 A调节人细胞中NF-κB活化，表明cGMP信号通路对先天免疫中NF-κB活化的调节在进化上是保守的。果蝇NF-κB信号传导由Gyc 76 C激活，与Toll受体平行Gyc 76 C通过下游Toll受体组分调节NF-κB信号传导在果蝇中，该途径包括cGMP依赖性蛋白激酶（cGK）和PP 2 A在人类细胞中，膜结合的cGK PRKG 2也通过PP 2 A调节NF-κB信号传导生物科学;免疫反应;基因组学
The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved. Drosophila NF-κB signaling is activated by Gyc76C in parallel with the Toll receptor Gyc76C modulates NF-κB signaling through downstream Toll receptor components In Drosophila, the pathway comprises a cGMP-dependent protein kinase (cGK) and PP2A In human cells, a membrane-bound cGK, PRKG2, also modulates NF-κB signaling via PP2A Biological sciences; Immune response; Genomics
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影响因子：
4.3
作者：
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