Acute Antibody-Mediated Rejection in Presence of MICA-DSA and Successful Renal Re-Transplant with Negative-MICA Virtual Crossmatch.
Acute Antibody-Mediated Rejection in Presence of MICA-DSA and Successful Renal Re-Transplant with Negative-MICA Virtual Crossmatch.
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MICA-DSA 存在下的急性抗体介导的排斥反应以及阴性 MICA 虚拟交叉配型成功的肾再移植。
DOI：
10.1371/journal.pone.0127861
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zou Y
中科院分区：
文献类型：
--
作者：
Ming Y;Hu J;Luo Q;Ding X;Luo W;Zhuang Q;Zou Y
针对MICA抗原的供体特异性同种抗体（dsa）的存在导致移植肾发生抗体介导的排斥反应（AMR）的高风险，特别是在接受再次移植的患者中。我们描述急性C4d+ AMR的发生率患者谁接受了第一次肾移植与零HLA抗原错配。回顾性分析移植后T细胞和B细胞交叉配型均为阴性，但在移植前和移植后收集的血清中均检测到高水平的MICA同种抗体。受体对第一个异体MICA*018失配的DSA存在。用5个新鲜分离的人脐静脉内皮细胞样本进行的流式细胞术和细胞毒性试验表明，患者的MICA-DSA具有同种异体抗体性质。在第二次移植之前，使用MICA虚拟交叉配型和T细胞和B细胞交叉配型来确定合适的供体。患者接受了第二次肾移植，在一年的随访中，同种异体移植功能良好。我们的研究表明，MICA虚拟交叉配型在选择肾供体时是重要的，如果受体已与MICA抗原致敏。
The presence of donor-specific alloantibodies (DSAs) against the MICA antigen results in high risk for antibody-mediated rejection (AMR) of a transplanted kidney, especially in patients receiving a re-transplant. We describe the incidence of acute C4d+ AMR in a patient who had received a first kidney transplant with a zero HLA antigen mismatch. Retrospective analysis of post-transplant T and B cell crossmatches were negative, but a high level of MICA alloantibody was detected in sera collected both before and after transplant. The DSA against the first allograft mismatched MICA*018 was in the recipient. Flow cytometry and cytotoxicity tests with five samples of freshly isolated human umbilical vein endothelial cells demonstrated the alloantibody nature of patient’s MICA-DSA. Prior to the second transplant, a MICA virtual crossmatch and T and B cell crossmatches were used to identify a suitable donor. The patient received a second kidney transplant, and allograft was functioning well at one-year follow-up. Our study indicates that MICA virtual crossmatch is important in selection of a kidney donor if the recipient has been sensitized with MICA antigens.
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影响因子：
6.2
作者：
Montgomery, RA;Hardy, MA;Zachary, AA
通讯作者：
Zachary, AA
影响因子：
2.7
作者：
Qin, Zhiqiang;Zou, Yizhou;Stastny, Peter
通讯作者：
Stastny, Peter
影响因子：
1.5
作者：
Vasilescu, ER;Ho, EK;Mancini, D
通讯作者：
Mancini, D
影响因子：
4.4
作者：
Goers, Trudie A.;Ramachandran, Sabarinathan;Mohanakumar, Thalachallour
通讯作者：
Mohanakumar, Thalachallour
影响因子：
3.2
作者：
Zou, Yizhou;Qin, Zhiqiang;Stastny, Peter
通讯作者：
Stastny, Peter