A clinical analysis of risk factors for interstitial lung disease in patients with idiopathic inflammatory myopathy.
A clinical analysis of risk factors for interstitial lung disease in patients with idiopathic inflammatory myopathy.
复制标题
特发性炎症性肌病患者间质性肺病危险因素的临床分析
DOI：
10.1155/2013/648570
复制
发表时间：
2013
影响因子：
--
通讯作者：
Xie Q
中科院分区：
文献类型：
--
作者：
Cen X;Zuo C;Yang M;Yin G;Xie Q
间质性肺病（ILD）是特发性炎性肌病（IIM）的常见和严重并发症。本研究的目的是通过评估有或无ILD的IIM患者的临床和生化特征来确定ILD的危险因素。从2008年1月至2011年12月，134例IIM患者在我们的风湿科的医疗记录进行了审查。将患者分为ILD组（83例）和非ILD组（51例）。比较两组患者的临床表现和实验室检查结果。单变量分析表明，关节炎/关节痛（54.2%vs17.6%，P < 0.05），机械手雷诺现象（16.9%vs2.0%，P < 0.05）（36.1%对2.0%，P < 0.05），（44.6%vs19.6%，P < 0.05），发热（43.4%对21.6%，P < 0.05），ESR升高（60.2%对35.3%，P < 0.05）、CRP升高（55.4%对31.4%，P < 0.05）或抗Jo-1抗体（20.5%对5.9%，P < 0.05）是IIM患者发生ILD的危险因素。多变量非条件Logistic回归分析显示关节炎/关节痛（OR 7.1，95% CI 2.8-18.1）、雷诺现象（OR 29.1，95% CI 3.6-233.7）和无肌病性皮肌炎（ADM）（OR 20.2，95% CI 2.4-171.2）是IIM患者发生ILD的独立危险因素。
Interstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM). The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in IIM patients with or without ILD. From January 2008 to December 2011, medical records of 134 IIM patients in our rheumatology unit were reviewed. The patients were divided into ILD group (83 patients) and non-ILD group (51 patients). The clinical features and laboratory findings were compared. The univariable analyses indicated that arthritis/arthralgia (54.2% versus 17.6%, P < 0.05), Mechanic's hand (16.9% versus 2.0%, P < 0.05), Raynaud's phenomenon (36.1% versus 2.0%, P < 0.05), heliotrope rash (44.6% versus 19.6%, P < 0.05), fever (43.4% versus 21.6%, P < 0.05), elevated ESR (60.2% versus 35.3%, P < 0.05), elevated CRP (55.4% versus 31.4%, P < 0.05), or anti-Jo-1 antibody (20.5% versus 5.9%, P < 0.05) were risk factors for developing ILD in IIM. Multivariable unconditional logistic regression analysis that showed arthritis/arthralgia (OR 7.1, 95% CI 2.8–18.1), Raynaud's phenomenon (OR 29.1, 95% CI 3.6–233.7), and amyopathic dermatomyositis (ADM) (OR 20.2, 95% CI 2.4–171.2) were the independent risk factors for developing ILD in IIM.
登录
查看更多内容
影响因子：
4
作者：
Vancsa, Andrea;Csipo, I.;Danko, K.
通讯作者：
Danko, K.
影响因子：
3.4
作者：
Ye, Shuang;Chen, Xiao-xiang;Chen, Shun-le
通讯作者：
Chen, Shun-le
影响因子：
9.6
作者：
Mukae, Hiroshi;Ishimoto, Hiroshi;Kohno, Shigeru
通讯作者：
Kohno, Shigeru
DOI：
10.1002/art.10794
发表时间：
2002-12-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Marie, I;Hachulla, E;Courtois, H
通讯作者：
Courtois, H
影响因子：
5.5
作者：
Kang, EH;Lee, EB;Song, YW
通讯作者：
Song, YW