Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model.
Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model.
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大鼠中风模型中 C7 神经切断术后神经分裂部位影响疼痛相关行为和脊髓胶质细胞增殖
DOI：
10.1155/2022/7446482
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发表时间：
2022
影响因子：
2.9
通讯作者：
Gu L
中科院分区：
文献类型：
--
作者：
Li Z;Fang J;Yang J;Qin B;He W;Qi J;Zhu Q;Wang H;Gu L
目的探讨C7神经切除部位对脑卒中模型大鼠瘫痪侧脊髓胶质细胞活化及疼痛相关行为的影响。方法雄性Sprague-Dawley大鼠大脑中动脉闭塞（MCAO）后，在瘫痪侧椎间孔远端0、2、4 mm处行C7神经切断术。评估疼痛相关行为和免疫荧光检测同侧C7背角脊髓胶质细胞活化。结果C7神经切开术部位与椎间孔的距离从4 mm减小到0 mm，机械爪退缩阈值（MPWT）降低，小胶质细胞和星形胶质细胞数量（/mm2）增加。结论C7神经切除部位影响MCAO大鼠MPWT及脊髓胶质细胞增殖。靠近椎间孔的神经分裂导致MPWT较低，脊髓胶质细胞增殖程度较高。
Objective This study aimed to evaluate whether the site of C7 neurotomy affects spinal cord glial cell activation and pain-related behavior on the paralyzed side in a rat stroke model. Methods After middle cerebral artery occlusion (MCAO) was induced in male Sprague-Dawley rats, they underwent C7 neurotomy 0, 2, and 4 mm distal to the intervertebral foramen on the paralyzed side. Pain-related behavior and immunofluorescence examination of spinal cord glial cell activation in the ipsilateral C7 dorsal horn were evaluated. Results Mechanical paw withdrawal threshold (MPWT) was lower, and the number of microglia and astrocytes (/mm2) was higher as the distance between the site of C7 neurotomy and the intervertebral foramen decreased from 4 mm to 0. Conclusion The site of C7 neurotomy affects MPWT and spinal cord glial proliferation in rats with MCAO. Nerve division closer to intervertebral foramen resulted in lower MPWT and higher degree of glial proliferation in the spinal cord.
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影响因子：
2.9
作者：
Gu, YM;Spasic, Z;Wu, WT
通讯作者：
Wu, WT
影响因子：
5.8
作者：
Coleman ER;Moudgal R;Lang K;Hyacinth HI;Awosika OO;Kissela BM;Feng W
通讯作者：
Feng W
缺血性中风：实验模型和现实。
影响因子：
12.7
作者：
Sommer CJ
通讯作者：
Sommer CJ
影响因子：
2.4
作者：
Li, PeiYang;Shen, Yundong;Xu, Wendong
通讯作者：
Xu, Wendong
影响因子：
7.4
作者：
BENNETT, GJ;XIE, YK
通讯作者：
XIE, YK