Role of multifaceted regulators in cancer glucose metabolism and their clinical significance.
Role of multifaceted regulators in cancer glucose metabolism and their clinical significance.
复制标题
多方面调控因子在癌症糖代谢中的作用及其临床意义
DOI：
10.18632/oncotarget.7765
复制
发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Zhao L;Mao Y;Zhao Y;Cao Y;Chen X
糖代谢异常，即“有氧糖酵解”或“瓦尔堡效应”，是人类癌症的标志。存在一组“多面调节器”，其在糖代谢的调节中起着关键作用。它们不仅可以调节特定酶的活性，还可以作为转录激活因子调节代谢相关基因的表达。此外，它们可以与参与葡萄糖代谢的其他关键因素相互作用，并共同启动多种致癌过程。这些“多方面的调节因子”，特别是p53，HIF-1，TIGAR和microRNA，将在这次审查中集中。本文将全面阐述其对肿瘤糖代谢的调节作用，并进一步阐述其临床意义。深入阐明“多面调节因子”在肿瘤糖代谢中的作用，将为肿瘤研究领域提供新的思路，并为肿瘤治疗提供有前景的治疗靶点。
Aberrant glucose metabolism, “aerobic glycolysis” or “Warburg effect”, is a hallmark of human cancers. There is a cluster of “multifaceted regulators”, which plays a pivotal role in the regulation of glucose metabolism. They can not only modulate the activities of specific enzymes, but also act as transcriptional activators to regulate the expression of metabolism related genes. Additionally, they can crosstalk with other key factors involved in glucose metabolism and work together to initiate multiple oncogenic processes. These “multifaceted regulators”, especially p53, HIF-1, TIGAR and microRNA, will be focused in this review. And we will comprehensively illustrate their regulatory effects on cancer glucose metabolism, and further elaborate on their clinical significance. In-depth elucidation the role of “multifaceted regulators” in cancer glucose metabolism will provide us novel insights in cancer research field and offer promising therapeutic targets for anti-cancer therapies.
登录
查看更多内容
DOI：
10.1073/pnas.1320243111
发表时间：
2014-02-18
影响因子：
11.1
作者：
Ahn, G-One;Seita, Jun;Brown, J. Martin
通讯作者：
Brown, J. Martin
Warburg效应：对既定概念的发展解释。
影响因子：
7.4
作者：
Chen, Xiaozhuo;Qian, Yanrong;Wu, Shiyong
通讯作者：
Wu, Shiyong
影响因子：
6.2
作者：
Elf SE;Chen J
通讯作者：
Chen J
MicroRNA-143 (miR-143) 通过靶向己糖激酶 2 基因调节癌症糖酵解
影响因子：
4.8
作者：
Fang, Rong;Xiao, Tian;Ji, Hongbin
通讯作者：
Ji, Hongbin
影响因子：
3.5
作者：
Fei, Xiang;Qi, Manlong;Li, Tingting
通讯作者：
Li, Tingting