Prospective study of mother-to-infant transmission of hepatitis C virus.
Prospective study of mother-to-infant transmission of hepatitis C virus.
复制标题
丙型肝炎病毒母婴传播的前瞻性研究。
DOI：
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复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
S. Okada
中科院分区：
文献类型：
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作者：
H. Tajiri;Y. Miyoshi;Shunpei Funada;Y. Etani;Jiro Abe;Takashi Onodera;M. Goto;M. Funato;S. Ida;C. Noda;M. Nakayama;S. Okada
背景
由于目前尚无预防垂直感染的方法，丙型肝炎病毒（HCV）母婴传播可能成为未来HCV感染的主要途径。本研究的目的是确定抗 HCV 抗体检测呈阳性的母亲所生婴儿的母婴传播发生率，并阐明传播的相关危险因素。
方法
对16,800名孕妇进行了抗HCV抗体检测，其中154名母亲呈阳性。阳性组中的 141 名母亲参加了这项研究，并对她们的 147 名婴儿从出生起进行血清丙氨酸转氨酶活性、抗 HCV 抗体和 HCV RNA 的跟踪。 141 名母亲中的 73 名接受了 HIV 感染检测，结果均为阴性。
结果
33 名婴儿因随访时间不足 6 个月或未进行充分测试而被退出研究。最终评估的 114 名婴儿中，有 9 名（7.8%）可检测到 HCV RNA。传播率不受分娩方式[阴道分娩，90 例中有 8 例 vs 剖腹产，24 例中有 1 例 (P = 0.396)] 或喂养类型的影响 [母乳喂养婴儿 98 例中有 9 例 vs 配方奶喂养婴儿 16 例中有 0 例 (P = 0.243)]。所有感染婴儿的母亲在分娩时患有 HCV 病毒血症 (P = 0.040) 以及病毒载量较高的母亲 (P = 0.019)。
结论
我们的前瞻性研究显示，抗HCV抗体阳性母亲的HCV母婴传播率为7.8%。风险与母亲分娩时存在 HCV 病毒血症以及母亲体内的高病毒载量有关。
BACKGROUND
Mother-to-infant transmission of hepatitis C virus (HCV) could become the main route of HCV infection in the future because there are no methods available to prevent vertical infection. The aim of this study was to determine the incidence of mother-to-infant transmission in infants born to mothers who tested positive for anti-HCV antibodies and to elucidate associated risk factors for transmission.
METHODS
Screening was conducted for 16,800 pregnant women with an anti-HCV antibodies test, and 154 mothers were positive. From the positive group 141 mothers were enrolled in the study and their 147 infants were followed from birth for serum alanine aminotransferase activity, anti-HCV antibodies and HCV RNA. HIV infection was tested in 73 of 141 mothers, all of whom were negative.
RESULTS
Thirty-three infants were dropped from the study because they were followed for <6 months or were not tested adequately. Of the 114 infants finally evaluated 9 (7.8%) had detectable HCV RNA. The transmission rate was not influenced by the mode of delivery [vaginal delivery, 8 of 90 vs. cesarean section, 1 of 24 (P = 0.396)] or by the type of feeding [9 of 98 for breast-fed infants vs. 0 of 16 for formula-fed infants (P = 0.243)]. All infected infants were born to mothers who had HCV viremia at the delivery (P = 0.040) and to those with a high viral load (P = 0.019).
CONCLUSIONS
Our prospective study showed that the transmission rate of mother-to-infant HCV infection was 7.8% in anti-HCV antibody-positive mothers. Risk was related to the presence of maternal HCV viremia at delivery and a high viral load in the mothers.
母亲静脉注射街头毒品的婴儿感染丙型肝炎病毒。
DOI：
10.1016/s0022-3476(05)83035-5
发表时间：
1991
期刊：
The Journal of pediatrics
影响因子：
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作者：
Weintrub,PS;Veereman-Wauters,G;Cowan,MJ;Thaler,MM
通讯作者：
Thaler,MM