Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.
Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.
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DOI：
10.1111/j.1471-4159.2008.05765.x
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发表时间：
2009-01
影响因子：
4.7
通讯作者：
Møller M
中科院分区：
文献类型：
--
作者：
Rath MF;Bailey MJ;Kim JS;Coon SL;Klein DC;Møller M
Pax4是一个编码Pax4的同源盒基因，Pax4是一种转录因子，对内分泌胰腺的胚胎发育至关重要。在胰腺中，Pax4抵消了相关转录因子Pax6的影响，Pax6是已知的眼睛形态发生所必需的。在本研究中，我们发现Pax4在大鼠的视网膜光感受器中有强烈的表达。Pax4在胎儿眼中没有表达；然而，出生后Pax4的转录水平迅速上升。相反，Pax6表现出相反的发育模式，在胎儿眼睛中表达更强。组织学分析显示，Pax4mRNA仅在视网膜光感受器中表达，而Pax6mRNA和蛋白存在于成熟视网膜的内核层和节细胞层。在成年视网膜中，Pax4转录本表现出昼夜节律，最高水平出现在光照期间，而视网膜Pax6转录本水平在一天中不变。Pax4表达的日常变化可能与分化的视网膜光感受器功能的日常变化有关。
Pax4 is a homeobox gene encoding Pax4, a transcription factor that is essential for embryonic development of the endocrine pancreas. In the pancreas, Pax4 counters the effects of the related transcription factor, Pax6, which is known to be essential for eye morphogenesis. In this study, we have discovered that Pax4 is strongly expressed in retinal photoreceptors of the rat. Pax4 expression is not detectable in the foetal eye; however, postnatal Pax4 transcript levels rapidly increase. In contrast, Pax6 exhibits an inverse developmental pattern of expression being more strongly expressed in the foetal eye. Histological analysis revealed that Pax4 mRNA is exclusively expressed in the retinal photoreceptors, whereas Pax6 mRNA and protein are present in the inner nuclear layer and in the ganglion cell layer of the mature retina. In the adult retina, Pax4 transcripts exhibit a diurnal rhythm with maximal levels occurring during the light period, whereas retinal Pax6 transcript levels do not change throughout the day. The daily changes in Pax4 expression may contribute to daily changes in function in the differentiated retinal photoreceptor.
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影响因子：
16.2
作者：
Chen, SM;Wang, QL;Zack, DJ
通讯作者：
Zack, DJ
DOI：
10.1016/s0169-328x(00)00160-1
发表时间：
2000-09-30
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Chen, W;Baler, R
通讯作者：
Baler, R
影响因子：
64.8
作者：
HILL, RE;FAVOR, J;VANHEYNINGEN, V
通讯作者：
VANHEYNINGEN, V
影响因子：
7.8
作者：
GONZALEZFERNANDEZ, F;HEALY, JI
通讯作者：
HEALY, JI
影响因子：
30.8
作者：
Furukawa, T;Morrow, EM;Cepko, CL
通讯作者：
Cepko, CL