Pathogenic adaptations to host-derived antibacterial copper.
Pathogenic adaptations to host-derived antibacterial copper.
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DOI：
10.3389/fcimb.2014.00003
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发表时间：
2014
影响因子：
5.7
通讯作者：
Henderson JP
中科院分区：
文献类型：
--
作者：
Chaturvedi KS;Henderson JP
最近的研究结果表明，宿主和病原体在感染期间都会操纵受感染宿主生态位中的铜含量。在这篇综述中，我们总结了最近的事态发展，牵连铜抗性作为一个重要的决定因素的细菌健身在主机-病原体接口。作为哺乳动物的一种必需营养素，铜在生理条件下在铜（I）（Cu+）的还原形式和铜（II）（Cu 2+）的氧化形式之间循环。Cu+比Cu 2+具有更强的杀菌能力，这是由于其能够自由地穿透细菌膜并破坏细胞内的铁-硫簇。铜离子还可以催化活性氧（ROS）的产生，这可能进一步导致其毒性。转运蛋白、分子伴侣、氧化还原蛋白、受体和转录因子，甚至铁载体都影响铜在病原微生物及其人类宿主中的积累和分布。本文将简要介绍铜作为哺乳动物抗菌效应物的证据，这种毒性的可能原因，以及针对它的致病耐药机制。
Recent findings suggest that both host and pathogen manipulate copper content in infected host niches during infections. In this review, we summarize recent developments that implicate copper resistance as an important determinant of bacterial fitness at the host-pathogen interface. An essential mammalian nutrient, copper cycles between copper (I) (Cu+) in its reduced form and copper (II) (Cu2+) in its oxidized form under physiologic conditions. Cu+ is significantly more bactericidal than Cu2+ due to its ability to freely penetrate bacterial membranes and inactivate intracellular iron-sulfur clusters. Copper ions can also catalyze reactive oxygen species (ROS) generation, which may further contribute to their toxicity. Transporters, chaperones, redox proteins, receptors and transcription factors and even siderophores affect copper accumulation and distribution in both pathogenic microbes and their human hosts. This review will briefly cover evidence for copper as a mammalian antibacterial effector, the possible reasons for this toxicity, and pathogenic resistance mechanisms directed against it.
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影响因子：
30.8
作者：
BULL, PC;THOMAS, GR;COX, DW
通讯作者：
COX, DW
影响因子：
14.8
作者：
Chaturvedi, Kaveri S.;Hung, Chia S.;Crowley, Jan R.;Stapleton, Ann E.;Henderson, Jeffrey P.
通讯作者：
Henderson, Jeffrey P.
影响因子：
3.6
作者：
BROWN, NL;BARRETT, SR;ROUCH, DA
通讯作者：
ROUCH, DA
影响因子：
4.1
作者：
Achard, Maud E. S.;Stafford, Sian L.;McEwan, Alastair G.
通讯作者：
McEwan, Alastair G.
影响因子：
4.4
作者：
Andreini, Claudia;Banci, Lucia;Rosato, Antonio
通讯作者：
Rosato, Antonio