The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer.
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer.
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DOI：
10.1016/j.semcdb.2012.01.007
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发表时间：
2012-06
影响因子：
7.3
通讯作者：
Girnun, Geoffrey D.
中科院分区：
文献类型：
--
作者：
Girnun, Geoffrey D.
近年来，细胞代谢改变在促进和维持癌症表型中发挥的关键作用受到了广泛关注。多年来，人们认为有氧糖酵解（也称为瓦伯格效应）在癌症中发挥着重要作用。然而，最近的研究强调了癌症中线粒体功能、氧化磷酸化和生物合成途径的需求。这引起了人们对控制这些代谢途径的机制的兴趣。 PPARγ 共激活因子 (PGC)-1 转录共激活因子家族已成为多种代谢途径的关键调节因子，包括氧化代谢、能量稳态以及葡萄糖和脂质代谢。虽然 PGC-1 与许多代谢疾病有关，但最近的研究强调了 PGC-1 在癌症中的重要作用。研究表明 PGC-1 具有促癌和抗癌功能，并表明 PGC-1 在癌症中发挥着动态作用。我们在这篇综述中讨论了 PGC-1 与癌症之间的联系，重点关注研究最深入的家族成员 PGC-1α。
The critical role that altered cellular metabolism plays in promoting and maintaining the cancer phenotype has received considerable attention in recent years. For many years it was believed that aerobic glycolysis, also known as the Warburg Effect, played an important role in cancer. However, recent studies highlight the requirement of mitochondrial function, oxidative phosphorylation and biosynthetic pathways in cancer. This has promoted interest into mechanisms controlling these metabolic pathways. The PPARγ coactivator (PGC)-1 family of transcriptional coactivators have emerged as key regulators of several metabolic pathways including oxidative metabolism, energy homeostasis and glucose and lipid metabolism. While PGC-1s have been implicated in a number of metabolic diseases, recent studies highlight an important role in cancer. Studies show that PGC-1s have both pro and anticancer functions and suggests a dynamic role for the PGC-1s in cancer. We discuss in this review the links between PGC-1s and cancer, with a focus on the most well studied family member, PGC-1α.
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影响因子：
11.2
作者：
Chajes, Veronique;Cambot, Marie;Joulin, Virginie
通讯作者：
Joulin, Virginie
影响因子：
4.8
作者：
Espinoza, Daniel O.;Boros, Laszlo G.;Patti, Mary-Elizabeth
通讯作者：
Patti, Mary-Elizabeth
影响因子：
50.3
作者：
Fantin, VR;Berardi, MJ;Leder, P
通讯作者：
Leder, P
影响因子：
8
作者：
Bauer, DE;Hatzivassiliou, G;Thompson, CB
通讯作者：
Thompson, CB
DOI：
10.1073/pnas.1016354108
发表时间：
2011-04-19
影响因子：
11.1
作者：
D'Errico, Ilenia;Salvatore, Lorena;Moschetta, Antonio
通讯作者：
Moschetta, Antonio