Diabetes and risk of renal cell carcinoma.
Diabetes and risk of renal cell carcinoma.
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DOI：
10.7150/jca.3718
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发表时间：
2012
影响因子：
3.9
通讯作者：
Werner SA
中科院分区：
文献类型：
--
作者：
Habib SL;Prihoda TJ;Luna M;Werner SA
背景和目的：有证据表明，糖尿病患者实体瘤的发生率明显增加。在目前的研究中，我们调查了糖尿病和肾癌之间的联系。患者和方法：对473例肾细胞癌(RCC)行肾切除术的患者进行单中心回顾性分析。对糖尿病肾细胞癌患者进行了年龄、性别、种族、糖化血红蛋白、血糖水平和肾功能的筛查。结果：在473例肾细胞癌患者中，120例(25.4%)有糖尿病病史。肾癌患者的糖尿病发病率在女性高于男性，在西班牙裔患者中高于白人和其他种族背景。确诊时，大多数糖尿病肾细胞癌患者年龄在50-59岁之间。在糖尿病肾细胞癌中，透明细胞型(92.0%)、核分级2级(56.1%)和肿瘤大小在1~5 cm之间(65.7%)是各类型中最常见的。结论：糖尿病肾细胞癌患者以局限性小透明细胞肾细胞癌为主。此外，与男性相比，有肾癌病史的女性患糖尿病的几率更高。这是首次报道糖尿病合并肾细胞癌的临床和组织病理学特征。
Background and objectives: There is evidence that the incidence of solid tumors is markedly increased in patients with diabetes mellitus. In the current study, we investigate the association between diabetes and renal cancer. Patients and Methods: A single-center retrospective analysis of 473 patients who underwent nephrectomy for renal cell carcinoma (RCC) was performed. Diabetic RCC patients were screened for age, gender, ethnicity, HgA1C, glucose levels and renal function. Results: Of the 473 cases with RCC, we identified 120 patients (25.4%) with a history of diabetes. The incidence of diabetes in RCC patients was higher in female than male subjects and in Hispanic compared to White and Other ethnic backgrounds. At diagnosis, the majority of diabetic RCC patients were 50-59 years of age. In diabetic RCC cases, clear cell type histology (92.0%), nuclear grade 2 (56.1%) and tumor size range from 1-5 cm (65.7%) were the most common in each category. Conclusion: Our findings indicate that diabetic RCC patients have a predominance of localized, small clear cell RCC. In addition, females with a history of RCC have a higher frequency of diabetes compared to males. This is the first report of clinical and histopathological features of RCC associated with diabetes.
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影响因子：
4.5
作者：
Lowrance WT;Thompson RH;Yee DS;Kaag M;Donat SM;Russo P
通讯作者：
Russo P
影响因子：
5
作者：
Rodriguez, C;Patel, AV;Calle, EE
通讯作者：
Calle, EE
DOI：
10.1053/j.arrt.2003.10.006
发表时间：
2004-01-01
期刊：
ADVANCES IN RENAL REPLACEMENT THERAPY
影响因子：
--
作者：
Lopes, AA
通讯作者：
Lopes, AA
影响因子：
6.4
作者：
Atchison, Elizabeth A.;Gridley, Gloria;Carreon, J. Daniel;Leitzmann, Michael F.;McGlynn, Katherine A.
通讯作者：
McGlynn, Katherine A.
影响因子：
4.2
作者：
Giovannucci, E
通讯作者：
Giovannucci, E