Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.
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DOI：
10.1111/bju.14412
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发表时间：
2019-03
影响因子：
4.5
通讯作者：
Aaronson NK
中科院分区：
文献类型：
--
作者：
Bancroft EK;Saya S;Page EC;Myhill K;Thomas S;Pope J;Chamberlain A;Hart R;Glover W;Cook J;Rosario DJ;Helfand BT;Hutten Selkirk C;Davidson R;Longmuir M;Eccles DM;Gadea N;Brewer C;Barwell J;Salinas M;Greenhalgh L;Tischkowitz M;Henderson A;Evans DG;Buys SS;IMPACT Study Steering Committee;IMPACT Collaborators;Eeles RA;Aaronson NK
为了报告一项纵向社会心理研究的基线结果，该研究是IMPACT研究的一部分，IMPACT研究是一项针对BRCA1或BRCA2基因中已知致病性种系突变的男性进行靶向前列腺癌（PCa）筛查的多国调查。参加IMPACT研究的男性被邀请在每次年度筛查访问之前在合作地点完成一份调查问卷。问卷包括社会人口学特征和以下测量：医院焦虑和抑郁量表（HADS）、事件影响量表（IES）、36项简短健康调查（SF - 36）、前列腺癌纪念焦虑量表、修订癌症担忧量表、风险认知和知识。给出了基线问卷调查的结果。共有432名男性完成了问卷调查：分别有98名和160名BRCA1和BRCA2基因突变，174名为对照组（家族突变阴性）。参与者对PCa风险的感知受遗传状况的影响。知识水平较高，且与遗传状况无关。HADS和SF - 36的平均得分在报告的一般人群标准范围内，IES的平均得分在正常范围内。BRCA1/BRCA2携带者的IES平均入侵和回避得分明显高于对照组，并且在PCa风险认知增加的男性中更高。在多变量水平上，风险感知比遗传状态对IES评分的差异贡献更显著。这是第一个报道接受PCa筛查的BRCA1/BRCA2突变男性的社会心理特征的研究。在整个队列中没有检测到临床相关的一般或癌症特异性窘迫或生活质量差的水平。一小部分参与者报告了更高水平的痛苦，这表明需要提供前列腺癌筛查的医疗保健专业人员来识别这些风险因素，并为寻求前列腺癌筛查的男性提供额外的信息和支持。
To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi‐national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36‐item short‐form health survey (SF‐36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale‐Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF‐36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer‐specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
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