The PACE study: a randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI).
The PACE study: a randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI).
复制标题
DOI：
10.1186/1745-6215-10-114
复制
发表时间：
2009-12-14
期刊：
影响因子：
2.5
通讯作者：
Almeida OP
中科院分区：
文献类型：
--
作者：
Vidovich MR;Lautenschlager NT;Flicker L;Clare L;Almeida OP
来自观察性研究的研究证据表明，认知活动可以降低晚年认知障碍的风险以及痴呆症患者认知能力下降的速度。通过认知运动促进健康老龄化（PACE）研究旨在确定认知活动干预是否可以降低患有轻度认知障碍（MCI）的老年人的认知能力下降率。该研究将招募160名年龄在65岁或以上的社区居民，患有轻度认知障碍（MCI）。参与者将被随机分配到两个治疗组：非特定教育和认知活动。干预将包括10个90分钟的会议，每周两次，为期五周。该研究的主要结局指标是剑桥认知评分（CAMCOG）总评分较基线的变化。关注的次要结果包括记忆力、注意力、执行功能、情绪和生活质量的变化。将在基线评估后12、52和104周收集主要终点。拟议的项目将提供最佳可用证据，证明增加认知活动作为预防患有轻度认知障碍的老年人认知能力下降的策略的优点。我们预计，这项研究的结果将对循证预防策略的发展产生影响，以降低老年痴呆症风险人群的认知能力下降率。ACTRN12608000556347
Research evidence from observational studies suggests that cognitive activity reduces the risk of cognitive impairment in later life as well as the rate of cognitive decline of people with dementia. The Promoting Healthy Ageing with Cognitive Exercise (PACE) study has been designed to determine whether a cognitive activity intervention decreases the rate of cognitive decline amongst older adults with mild cognitive impairment (MCI). The study will recruit 160 community-dwelling men and women aged 65 years of age or over with mild cognitive impairment (MCI). Participants will be randomly allocated to two treatment groups: non-specific education and cognitive activity. The intervention will consist of ten 90-minute sessions delivered twice per week over a period of five weeks. The primary outcome measure of the study is the change from baseline in the total score on the Cambridge Cognitive Score (CAMCOG). Secondary outcomes of interest include changes in memory, attention, executive functions, mood and quality of life. Primary endpoints will be collected 12, 52 and 104 weeks after the baseline assessment. The proposed project will produce the best available evidence on the merits of increased cognitive activity as a strategy to prevent cognitive decline among older adults with MCI. We anticipate that the results of this study will have implications for the development of evidence-based preventive strategies to reduce the rate of cognitive decline amongst older people at risk of dementia. ACTRN12608000556347
登录
查看更多内容
影响因子：
11.4
作者：
Jamrozik, K;Norman, PE;Dickinson, JA
通讯作者：
Dickinson, JA
影响因子：
9.9
作者：
Wang, JYJ;Zhou, DHD;Chen, M
通讯作者：
Chen, M
影响因子：
158.5
作者：
Verghese, J;Lipton, RB;Buschke, H
通讯作者：
Buschke, H
影响因子：
3.3
作者：
Logsdon, RG;Gibbons, LE;Teri, L
通讯作者：
Teri, L
影响因子：
3.4
作者：
KOENIG, HG;WESTLUND, RE;HYBELS, C
通讯作者：
HYBELS, C