Effects of treatment with oxandrolone for 4 years on the frequency of severe arithmetic learning disability in girls with Turner syndrome.
Effects of treatment with oxandrolone for 4 years on the frequency of severe arithmetic learning disability in girls with Turner syndrome.
复制标题
氧雄龙治疗 4 年对特纳综合征女孩严重算术学习障碍频率的影响。
DOI：
10.1016/j.jpeds.2009.05.031
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Roeltgen,David
中科院分区：
文献类型：
--
作者：
Ross,JudithL;Mazzocco,MicheleMM;Kushner,Harvey;Kowal,Karen;CutlerJr,GordonB;Roeltgen,David
OBJECTIVESTo study androgen treatment effects on arithmetic performance in girls with Turner syndrome.STUDY DESIGNForty-four girls, ages 10 to 14 years at baseline, completed 4 years of treatment with oxandrolone (Ox) or placebo (Pl). All received growth hormone and estrogen replacement therapy. We assessed the number of girls with severe learning disability (LD, standard score ≤5thpercentile) on measures of academic arithmetic and reading achievement (WRAT-3, arithmetic and reading), given yearly, and the WIAT numerical operations (NOS) and reading subtests, given at year 4.RESULTSOn the WRAT-3 arithmetic, the frequency of severe arithmetic LD was similar in the Ox and Pl groups at baseline and at years 1 and 2. At years 3 and 4, fewer girls in the Ox than Pl group had a severe arithmetic LD (year 4: 0/22 vs 5/21, P = .02). On the WIAT NOS (year 4), fewer girls in the Ox than Pl groups had a severe arithmetic LD (3/21 vs 8/20, P = .09). WIAT NOS error analysis suggested that the improved performance in the Ox group was associated with better performance on multiplication and division (P < .01). The frequency of severe LD for the WRAT-3 reading was similar for the Ox and Pl groups (all years) and for the WIAT reading subtest (year 4).CONCLUSIONSAndrogen treatment for 4 years in girls with Turner syndrome resulted in a small decrease in frequency of severe arithmetic LD, with no effect on reading LD.
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影响因子：
2.2
作者：
Mazzocco, MMM;Bhatia, NS;Lesniak-Karpiak, K
通讯作者：
Lesniak-Karpiak, K
影响因子：
3.7
作者：
Kesler, Shelli R.;Menon, Vinod;Reiss, Allan L.
通讯作者：
Reiss, Allan L.
影响因子：
3
作者：
Mazzocco, MMM
通讯作者：
Mazzocco, MMM
影响因子：
5.1
作者：
ROSENFELD, RG;FRANE, J;JOHANSON, AJ
通讯作者：
JOHANSON, AJ
影响因子：
9.8
作者：
Ross, JL;Roeltgen, D;Zinn, AR
通讯作者：
Zinn, AR