Signaling pathways in obesity: mechanisms and therapeutic interventions.
Signaling pathways in obesity: mechanisms and therapeutic interventions.
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DOI：
10.1038/s41392-022-01149-x
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发表时间：
2022-08-28
影响因子：
39.3
通讯作者：
Li, Tao
中科院分区：
文献类型：
--
作者：
Wen, Xue;Zhang, Bohan;Wu, Beiyi;Xiao, Haitao;Li, Zehua;Li, Ruoyu;Xu, Xuewen;Li, Tao
肥胖是一种复杂的慢性疾病，也是全球公共卫生挑战。肥胖的特点是体内脂肪堆积过多，肥胖会急剧增加多种疾病的风险，例如2型糖尿病、心血管疾病和非酒精性脂肪肝，并与预期寿命降低有关。尽管生活方式干预（饮食和运动）对体重管理具有显着效果，但实现减肥的长期成功极具挑战性，而且全球肥胖患病率持续上升。在过去的几十年里，肥胖的病理生理学得到了广泛的研究，越来越多的信号转导途径与肥胖有关，使得以更有效和更精确的方式对抗肥胖成为可能。在这篇综述中，我们总结了实验和临床研究中肥胖发病机制的最新进展，重点关注信号通路及其在食物摄入、葡萄糖稳态、脂肪生成、产热和慢性炎症调节中的作用。我们还讨论了当前针对这些信号的抗肥胖药物以及临床试验中的减肥化合物。随着我们进入精准医学的新时代，信号转导知识的不断发展可能会揭示肥胖研究的未来方向。
Obesity is a complex, chronic disease and global public health challenge. Characterized by excessive fat accumulation in the body, obesity sharply increases the risk of several diseases, such as type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease, and is linked to lower life expectancy. Although lifestyle intervention (diet and exercise) has remarkable effects on weight management, achieving long-term success at weight loss is extremely challenging, and the prevalence of obesity continues to rise worldwide. Over the past decades, the pathophysiology of obesity has been extensively investigated, and an increasing number of signal transduction pathways have been implicated in obesity, making it possible to fight obesity in a more effective and precise way. In this review, we summarize recent advances in the pathogenesis of obesity from both experimental and clinical studies, focusing on signaling pathways and their roles in the regulation of food intake, glucose homeostasis, adipogenesis, thermogenesis, and chronic inflammation. We also discuss the current anti-obesity drugs, as well as weight loss compounds in clinical trials, that target these signals. The evolving knowledge of signaling transduction may shed light on the future direction of obesity research, as we move into a new era of precision medicine.
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