A glimpse of matrix metalloproteinases in diabetic nephropathy.
A glimpse of matrix metalloproteinases in diabetic nephropathy.
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DOI：
10.2174/0929867321666140716092052
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发表时间：
2014
影响因子：
4.1
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Xu X;Xiao L;Xiao P;Yang S;Chen G;Liu F;Kanwar YS;Sun L
基质金属蛋白酶（MMP）是属于锌依赖性内肽酶家族的蛋白水解酶，其能够降解细胞外基质（ECM）的几乎所有蛋白质组分。已知MMPs在许多肾脏疾病中起作用，例如各种形式的肾小球肾炎和肾小管疾病，包括一些遗传性肾脏疾病。在这方面，ECM积累被认为是糖尿病肾病的标志性形态学发现，其不仅与基质蛋白的过度合成有关，而且与基质蛋白降解减少有关。近年来，越来越多的证据表明，在人类糖尿病肾病患者和各种实验动物模型中，MMPs的活性或表达与肾脏疾病的进展之间存在良好的相关性。在这种糖尿病环境中，MMPs的表达受到高糖、晚期糖基化终产物（AGEs）、TGF-β、活性氧（ROS）、转录因子和一些microRNA的调节。本文就基质金属蛋白酶的结构、功能及其在糖尿病肾病发病中的作用作一综述。
Matrix metalloproteinases (MMPs) are proteolytic enzymes belonging to the family of zinc-dependent endopeptidases that are capable of degrading almost all the proteinaceous components of the extracellular matrix (ECM). It is known that MMPs play a role in a number of renal diseases, such as, various forms of glomerulonephritis and tubular diseases, including some of the inherited kidney diseases. In this regard, ECM accumulation is considered to be a hallmark morphologic finding of diabetic nephropathy, which not only is related to the excessive synthesis of matrix proteins, but also to their decreased degradation by the MMPs. In recent years, increasing evidence suggest that there is a good correlation between the activity or expression of MMPs and progression of renal disease in patients with diabetic nephropathy in humans and in various experimental animal models. In such a diabetic milieu, the expression of MMPs is modulated by high glucose, advanced glycation end products (AGEs), TGF-β, reactive oxygen species (ROS), transcription factors and some of the microRNAs. In this review, we focused on the structure and functions of MMPs, and their role in the pathogenesis of diabetic nephropathy.
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影响因子：
64.8
作者：
BODE, W;GOMISRUTH, FX;STOCKER, W
通讯作者：
STOCKER, W
影响因子：
14.5
作者：
Bourboulia D;Stetler-Stevenson WG
通讯作者：
Stetler-Stevenson WG
DOI：
10.1083/jcb.118.3.727
发表时间：
1992-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Alexander CM;Werb Z
通讯作者：
Werb Z
影响因子：
3.6
作者：
Boyd, Sonja;Virolainen, Susanna;Saarialho-Kere, Ulpu
通讯作者：
Saarialho-Kere, Ulpu
影响因子：
--
作者：
Aoyama, T;Yamamoto, S;Tabata, Y
通讯作者：
Tabata, Y