Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion.
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion.
复制标题
DOI：
10.1016/j.semcancer.2010.05.002
复制
发表时间：
2010-06
影响因子：
14.5
通讯作者：
Stetler-Stevenson WG
中科院分区：
文献类型：
--
作者：
Bourboulia D;Stetler-Stevenson WG
细胞彼此粘附和/或粘附到它们周围的基质上。正常细胞中细胞-细胞（细胞间）和细胞-基质粘附的调节受到严格控制，然而，细胞粘附的缺陷在大多数人类癌症中是常见的。肿瘤细胞与细胞外基质（ECM）和邻近细胞之间的多边通信是通过粘附分子、ECM组分、蛋白水解酶及其内源性抑制剂来完成的。有足够的证据表明，粘附性降低是肿瘤进展过程中肿瘤细胞的一种特性。肿瘤细胞获得了改变形状、分离和容易地移动通过扰乱正常组织结构的空间的能力。这种性质是由于粘附分子表达水平的变化和/或由于分泌的蛋白水解酶（包括基质金属蛋白酶（MMP））水平升高。在其他作用中，MMP降解ECM，因此为肿瘤细胞迁移、侵入和扩散到远处的继发区域准备路径，在那里它们形成转移。金属蛋白酶的组织抑制剂或TIMP控制MMP活性，因此使基质降解最小化。MMPs和TIMPs都参与组织重塑，并决定性地调节肿瘤细胞的进展，包括肿瘤血管生成。在这篇综述中，我们描述和讨论的数据支持的重要作用，基质金属蛋白酶和金属蛋白酶组织抑制剂在癌细胞粘附和肿瘤进展。
Cells adhere to one another and/or to matrices that surround them. Regulation of cell-cell (intercellular) and cell-matrix adhesion is tightly controlled in normal cells, however, defects in cell adhesion are common in the majority of humancancers. Multilateral communication among tumor cells with the extracellular matrix (ECM) and neighbor cells is accomplished through adhesion molecules, ECM components, proteolytic enzymes and their endogenous inhibitors. There is sufficient evidence to suggest that reduced adherence is a tumor cell propertyengaged during tumor progression. Tumor cells acquire the ability to change shape, detach and easily move through spaces disorganizing the normal tissue architecture. This property is due to changes in expression levels of adhesion molecules and/or due to elevated levels of secreted proteolytic enzymes, including matrix metalloproteinases (MMPs). Among other roles, MMPsdegrade the ECMand, therefore, prepare the path for tumor cells to migrate, invade and spread to distant secondary areas, where they form metastasis. Tissue Inhibitors of Metalloproteinases or TIMPs control MMP activities and, therefore, minimize matrix degradation. Both MMPs and TIMPs are involved in tissue remodeling and decisively regulate tumor cell progression including tumor angiogenesis. In this review, we describe and discuss data that support the important role of MMPs and TIMPs in cancer cell adhesion and tumor progression.
登录
查看更多内容
影响因子：
3.6
作者：
Gordon, Marion K.;Hahn, Rita A.
通讯作者：
Hahn, Rita A.
影响因子：
4.6
作者：
Guan, Jun-Lin
通讯作者：
Guan, Jun-Lin
影响因子：
64.8
作者：
GASSON, JC;GOLDE, DW;CLARK, SC
通讯作者：
CLARK, SC
影响因子：
3.6
作者：
Durbeej, Madeleine
通讯作者：
Durbeej, Madeleine
影响因子：
--
作者：
Birkedal-Hansen, Henning;Yamada, Susan;Birkedal-Hansen, Bente
通讯作者：
Birkedal-Hansen, Bente