Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells
Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells
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嗜酸性粒细胞分化因子 (Interleukin-5) 的分子和细胞生物学及其对人和小鼠 B 细胞的影响
DOI：
10.1111/j.1600-065x.1988.tb00740.x
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发表时间：
1988
影响因子：
8.7
通讯作者：
I. Young
中科院分区：
文献类型：
--
作者：
C. Sanderson;H. Campbell;I. Young
嗜酸性粒细胞在正常个体和动物的血液和组织中很少发现，但却是过敏反应和蠕虫感染的特征。在本世纪之交之前，它们独特的形态导致了它们在这些和其他疾病的血液和组织中存在的描述性报告。然而，与嗜中性粒细胞和巨噬细胞相比，它们在标准吞噬测定中相对不活跃，因此对其生物活性知之甚少，直到最近，它们在很大程度上仍然是血液学上的好奇心。这些早期的描述性报告都说明了嗜酸性粒细胞反应的程度，表明在特定情况下，它们可以成为主要的血液和组织白细胞，并建立了嗜酸性粒细胞增多症的发展和IgE抗体水平升高之间的明确关联。导致对嗜酸性粒细胞的生物学作用的理解增加的一个重要发展是其纯化技术的发展，首先是从人外周血（巴特沃思1975），这使得观察到人嗜酸性粒细胞能够杀死曼氏血吸虫的童虫成为可能。随后有一系列报告表明，人类嗜酸性粒细胞可以杀死各种蠕虫幼虫（Butterwheh 1984年审查）。后来从实验动物的腹膜渗出液中纯化嗜酸性粒细胞的技术清楚地表明，它们的细胞毒性能力不仅限于蠕虫。它们被证明具有很强的活性
Eosinophils are found only infrequently in the blood and tissues of normal individuals and animals, but are characteristic of allergic responses and infection by helminths. Their distinctive morphology led to descriptive reports of their presence in the blood and tissues in these and other diseases well before the turn of this century. However, compared to neutrophils and macrophages they are relatively inactive in standard phagocytosis assays and so little has been known about their biological activity and they remained, until recently, largely a hematological curiosity. These early descriptive reports both illustrated the magnitude of the eosinophil response, by showing that in particular circumstances they can become the predominant blood and tissue leukocyte, and established a clear association between the development of an eosinophilia and increased levels of IgE antibody. An important development which has led to an increased understanding of the biological role of the eosinophil was the development of techniques for their purification, firstly from human peripheral blood (Butterworth 1975), which made possible the observation that human eosinophils were capable of killing schistosomula of Schistosoma mansoni. This was followed by a series of reports indicating that human eosinophils could kill a wide variety of helminthic larvae (reviewed by Butterworlh 1984). Later techniques for purifying eosinophils from the peritoneal exudate of experimental animals made it clear that their cytotoxic capability was not limited to helminths. They were shown to have potent activity
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影响因子：
5.4
作者：
Kimura,H;Ishibashi,T;Uchida,T;Maruyama,Y;Friese,P;Burstein,SA
通讯作者：
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影响因子：
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作者：
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通讯作者：
G. Gleich;C. Adolphson
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.84.16.5913
发表时间：
1987
影响因子：
11.1
作者：
LeBeau,MM;Epstein,ND;O'Brien,SJ;Nienhuis,AW;Yang,YC;Clark,SC;Rowley,JD
通讯作者：
Rowley,JD
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影响因子：
20.3
作者：
Begley,CG;Lopez,AF;Nicola,NA;Warren,DJ;Vadas,MA;Sanderson,CJ;Metcalf,D
通讯作者：
Metcalf,D