Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.
Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.
复制标题
DOI：
10.1016/j.iac.2008.10.003
复制
发表时间：
2009-02
影响因子：
2.6
通讯作者：
Ackerman, Steven J.
中科院分区：
文献类型：
--
作者：
Aceves, Seema S.;Ackerman, Steven J.
关键词：
嗜酸粒细胞性食管炎（EE）的临床和病理特征包括广泛的组织重塑。越来越多的证据支持嗜酸性粒细胞在这种过敏性疾病的食管重塑和纤维化的多个方面发挥关键作用，包括上皮增生、上皮下纤维化、平滑肌增生和血管生成。这些结构变化导致内镜下发现食管增厚、管腔狭窄、皱褶、暂时性和固定环（气管化）和狭窄，以及儿童和成人 EE 中运动障碍、吞咽困难和食物嵌塞的临床特征。本章回顾了 EE 中食管重塑和纤维化的临床意义，并讨论了诱导和调节这些反应的可能致病机制。我们特别关注嗜酸性粒细胞和细胞因子与食管上皮、血管内皮、常驻成纤维细胞和平滑肌的相互作用。讨论了当前和潜在的治疗干预措施，这些干预措施可能会影响 EE 慢性食管重塑和纤维化的发展或解决。
The clinical and pathologic features of Eosinophilic Esophagitis (EE) include extensive tissue remodeling. Increasing evidence supports a key role for the eosinophil in multiple aspects of the esophageal remodeling and fibrosis seen in this allergic disease, including epithelial hyperplasia, subepithelial fibrosis, smooth muscle hyperplasia, and angiogenesis. These structural changes contribute to the endoscopic findings of esophageal thickening, luminal narrowing, furrowing, transient and fixed rings (trachealization) and stricture, as well as the clinical features of dysmotility, dysphagia and food impactions in pediatric and adult EE. This chapter reviews the clinical implications of esophageal remodeling and fibrosis in EE and discusses the possible pathogenic mechanisms inducing and regulating these responses. We focus specifically on eosinophil and cytokine interactions with the esophageal epithelium, vascular endothelium, resident fibroblasts, and smooth muscle. Current and potential therapeutic interventions are discussed that may impact the development or resolution of chronic esophageal remodeling and fibrosis in EE.
登录
查看更多内容
影响因子：
15.9
作者：
Evans, CM;Fryer, AD;Costello, RW
通讯作者：
Costello, RW
DOI：
10.1016/j.giec.2007.09.015
发表时间：
2008-01-01
影响因子：
--
作者：
Fox, Victor L
通讯作者：
Fox, Victor L
影响因子：
14.2
作者：
Assa'ad, Amal H.;Putnam, Philip E.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.
DOI：
10.1016/j.giec.2007.09.003
发表时间：
2008-01-01
影响因子：
--
作者：
Aceves, Seema S;Furuta, Glenn T;Spechler, Stuart Jon
通讯作者：
Spechler, Stuart Jon
影响因子：
4.8
作者：
Eickelberg, O;Pansky, A;Roth, M
通讯作者：
Roth, M