Can we safely target the WNT pathway?
Can we safely target the WNT pathway?
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我们可以安全地针对Wnt途径吗？
DOI：
10.1038/nrd4233
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
WNT-β-连环蛋白信号传导通过调节细胞增殖、分化、迁移、遗传稳定性和凋亡以及维持成体干细胞处于多能状态来参与多种发育过程和成体组织稳态的维持。毫不奇怪，该通路的异常调节与多种疾病有关，包括癌症、纤维化和神经变性。尽管有这些知识，专门针对 WNT 通路的治疗药物最近才进入临床试验，尚未获得批准。本评论探讨了这一令人烦恼的情况的问题和潜在解决方案，并试图正确看待它们。
WNT–β-catenin signalling is involved in a multitude of developmental processes and the maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation, migration, genetic stability and apoptosis, as well as by maintaining adult stem cells in a pluripotent state. Not surprisingly, aberrant regulation of this pathway is therefore associated with a variety of diseases, including cancer, fibrosis and neurodegeneration. Despite this knowledge, therapeutic agents specifically targeting the WNT pathway have only recently entered clinical trials and none has yet been approved. This Review examines the problems and potential solutions to this vexing situation and attempts to bring them into perspective.
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影响因子：
3.7
作者：
Aly H;Rohatgi N;Marshall CA;Grossenheider TC;Miyoshi H;Stappenbeck TS;Matkovich SJ;McDaniel ML
通讯作者：
McDaniel ML
影响因子：
8.8
作者：
Boon, E M J;Keller, J J;Wormhoudt, T A M;Giardiello, F M;Offerhaus, G J A;van der Neut, R;Pals, S T
通讯作者：
Pals, S T
影响因子：
11.2
作者：
Caldwell, GM;Jones, C;Morton, DG
通讯作者：
Morton, DG
影响因子：
9.8
作者：
Blackwood, DHR;Fordyce, A;Muir, WJ
通讯作者：
Muir, WJ
影响因子：
15.9
作者：
Beers, Michael F.;Morrisey, Edward E.
通讯作者：
Morrisey, Edward E.