The intestinal epithelial barrier: a therapeutic target?
The intestinal epithelial barrier: a therapeutic target?
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DOI：
10.1038/nrgastro.2016.169
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Turner JR
中科院分区：
文献类型：
--
作者：
Odenwald MA;Turner JR
肠上皮的基本功能是充当调节腔内容物（例如肠微生物群、底层免疫系统和身体其余部分）之间的相互作用的屏障，同时支持营养物、水和废物的载体运输。上皮屏障功能需要连续的细胞层以及密封上皮细胞之间的细胞旁空间的连接。受损的肠屏障功能与许多疾病状态相关，包括肠道和全身性疾病。不幸的是，目前的大多数临床数据是相关的，使得很难在解释屏障丧失的意义时将因果关系分开。来自实验动物模型的一些数据表明，受损的上皮完整性可能在特定的胃肠道疾病中起致病作用，但目前没有FDA批准的靶向上皮屏障的疗法。为了实现这一目标，必须更深入地了解疾病的发病机制和屏障调节机制。
A fundamental function of the intestinal epithelium is to act as a barrier that regulates interactions between the luminal contents, such as the intestinal microbiota, the underlying immune system, and the remainder of the body, while supporting vectorial transport of nutrients, water, and waste products. Epithelial barrier function requires a contiguous layer of cells as well as the junctions that seal the paracellular space between epithelial cells. Compromised intestinal barrier function has been associated with a number of disease states, both intestinal and systemic. Unfortunately, most current clinical data are correlative, making it difficult to separate cause from effect in interpreting significance of barrier loss. Some data from experimental animal models suggest that compromised epithelial integrity may play a pathogenic role in specific gastrointestinal diseases, but no FDA-approved therapies for targeting the epithelial barrier are presently available. In order for this goal to be achieved, a deeper understanding of both disease pathogenesis and mechanisms of barrier regulation must be reached.
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