Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT.
Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT.
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DOI：
10.1007/s00259-021-05282-7
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发表时间：
2021-07
影响因子：
9.1
通讯作者：
Rominger A
中科院分区：
文献类型：
--
作者：
Alberts I;Hünermund JN;Prenosil G;Mingels C;Bohn KP;Viscione M;Sari H;Vollnberg B;Shi K;Afshar-Oromieh A;Rominger A
目的：通过患者内比较，研究新型长轴向视野(LAFOV)Biograph Vision Quadra PET/CT和标准轴向视野(SAFOV)Biograph Vision 600 PET/CT(两者均为西门子医疗设备)系统的性能。44例接受常规肿瘤正电子发射计算机断层扫描/CT的患者在接受18F-FDG(n = 20)、18F-PSMA-1007(n = 16)或68Ga-DOTA-TOC(n = 8)的单次扫描后接受了当天的双扫描方案。其中一半患者先在连续床位运动的SAFOV(FOVaxal26.3 cm)上进行临床常规检查，然后立即在LAFOV系统上(列表模式下10分钟采集，FOVaxal106 cm)进行扫描；另一半患者按相反顺序进行扫描。比较不同模拟扫描时间的LAFOV与SAFOV在靶区积分活动度、信噪比(SNR)、靶区背景比(TBR)和视觉图像质量等方面的差异。在LAFOV上获得与SAFOV采集(16min持续106cmFOV)相当的靶区病变积分活动，时间为1.63 ± 0.19min(平均±标准误差)。通过采集1.82 ± 1.00min的LAFOV获得等效信噪比。即使在0.5min的LAFOV检查中，也没有观察到总胆红素受体的统计学差异(p >； 0.05)。由两名医生评定的主观图像质量证实，10min的LAFOV质量最高，LAFOV和SAFOV的等效性为1.8min± 0.85min。以此类推，如果LAFOV扫描保持在10分钟，按比例减少应用的放射性药物可以获得40 Mbq以下活动的等量病变积分活度和1 Msv的PET成分的等量剂量。在临床条件下的头对头比较中，LAFOV系统的图像质量、病变量化和信噪比因更高的灵敏度而得到改善。与常规的SAFOV采集(相当于视野覆盖的16分钟)相比，LAFOV系统可以在2分钟内提供质量相当的图像和病变量化。或者，LAFOV系统可以支持低剂量检查方案。较短的LAFOV采集(0.5min)，虽然具有较低的视觉质量和信噪比，但在目标病变识别方面具有足够的质量，这表明在选定的设置中，超快或低剂量采集是可以接受的。
To investigate the performance of the new long axial field-of-view (LAFOV) Biograph Vision Quadra PET/CT and a standard axial field-of-view (SAFOV) Biograph Vision 600 PET/CT (both: Siemens Healthineers) system using an intra-patient comparison. Forty-four patients undergoing routine oncological PET/CT were prospectively included and underwent a same-day dual-scanning protocol following a single administration of either 18F-FDG (n = 20), 18F-PSMA-1007 (n = 16) or 68Ga-DOTA-TOC (n = 8). Half the patients first received a clinically routine examination on the SAFOV (FOVaxial 26.3 cm) in continuous bed motion and then immediately afterwards on the LAFOV system (10-min acquisition in list mode, FOVaxial 106 cm); the second half underwent scanning in the reverse order. Comparisons between the LAFOV at different emulated scan times (by rebinning list mode data) and the SAFOV were made for target lesion integral activity, signal to noise (SNR), target lesion to background ratio (TBR) and visual image quality. Equivalent target lesion integral activity to the SAFOV acquisitions (16-min duration for a 106 cm FOV) were obtained on the LAFOV in 1.63 ± 0.19 min (mean ± standard error). Equivalent SNR was obtained by 1.82 ± 1.00 min LAFOV acquisitions. No statistically significant differences (p > 0.05) in TBR were observed even for 0.5 min LAFOV examinations. Subjective image quality rated by two physicians confirmed the 10 min LAFOV to be of the highest quality, with equivalence between the LAFOV and the SAFOV at 1.8 ± 0.85 min. By analogy, if the LAFOV scans were maintained at 10 min, proportional reductions in applied radiopharmaceutical could obtain equivalent lesion integral activity for activities under 40 MBq and equivalent doses for the PET component of <1 mSv. Improved image quality, lesion quantification and SNR resulting from higher sensitivity were demonstrated for an LAFOV system in a head-to-head comparison under clinical conditions. The LAFOV system could deliver images of comparable quality and lesion quantification in under 2 min, compared to routine SAFOV acquisition (16 min for equivalent FOV coverage). Alternatively, the LAFOV system could allow for low-dose examination protocols. Shorter LAFOV acquisitions (0.5 min), while of lower visual quality and SNR, were of adequate quality with respect to target lesion identification, suggesting that ultra-fast or low-dose acquisitions can be acceptable in selected settings.
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影响因子：
4
作者：
Koopman D;van Osch JA;Jager PL;Tenbergen CJ;Knollema S;Slump CH;van Dalen JA
通讯作者：
van Dalen JA
DOI：
10.1007/s00259-019-4260-z
发表时间：
2019-06-01
影响因子：
9.1
作者：
Alfonso Lopez-Mora, Diego;Flotats, Albert;Carrio, Ignasi
通讯作者：
Carrio, Ignasi
DOI：
10.1186/s40644-016-0086-0
发表时间：
2016-08-26
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Yan J;Schaefferkoette J;Conti M;Townsend D
通讯作者：
Townsend D
影响因子：
9.3
作者：
Sandstrom, Mattias;Velikyan, Irina;Lubberink, Mark
通讯作者：
Lubberink, Mark
DOI：
10.1007/s00259-018-4256-0
发表时间：
2019-07-01
影响因子：
9.1
作者：
Fuentes-Ocampo, Francisco;Alfonso Lopez-Mora, Diego;Carrio, Ignasi
通讯作者：
Carrio, Ignasi