The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population.
The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population.
复制标题
铝在门诊血液透析人群贫血发病机制中的作用。
DOI：
10.3109/08860228909066949
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发表时间：
1989
期刊：
影响因子：
3
通讯作者：
J. Shapiro
中科院分区：
文献类型：
--
作者：
B. Yuan;M. Klein;R. Contiguglia;J. Mishell;P. Seligman;N. Miller;B. Molitoris;A. Alfrey;J. Shapiro
贫血是慢性透析患者铝负荷过高的明确并发症，可能在铝中毒的其他表现明显之前就出现了。慢性肾功能衰竭的贫血原因是多方面的，目前尚无铝致贫血的标记物。去铁胺(DFO)治疗可以纠正铝相关性贫血和小红细胞增多，但可能与副作用有关。由于红细胞中的铝可能在铝超载引起的贫血中起作用，我们试图检测红细胞(RBC)铝作为铝相关性贫血的标志物，并评估门诊透析人群中铝相关性贫血的患病率。随机血浆铝和红细胞铝都与DFO后血浆铝的升高有很好的相关性。然而，与血浆铝相比，红细胞铝受口服铝摄入量变化的影响较小。在我们的患者中，RBC和血浆铝与红细胞体积(MCV)有很强的相关性。此外，红细胞铝含量最高四分位数的患者的平均MCV(82.1+/-1.7比89.6+/-1.7，p<0.01)和红细胞压积(Hct)(24.3+/-4比28.2+/-1.5，p<0.05)低于最低四分位数的患者。提示铝中毒是门诊血液透析患者发生小细胞性贫血的重要原因。需要进行前瞻性的长期研究，以进一步确定红细胞铝在诊断和跟踪血液透析患者铝性贫血中的有效性。
Anemia is a well-defined complication of aluminum overload in chronic dialysis patients which may be present before other manifestations of aluminum toxicity are obvious. Causes of anemia in chronic renal failure are multiple, and at the present time there is no marker for aluminum-induced anemia. Deferoxamine (DFO) treatment can correct aluminum-related anemia and microcytosis, but may be associated with side effects. Because of the possible role of aluminum in red blood cells in causing the anemia associated with aluminum overload, we attempted to test red blood cell (RBC) aluminum as a marker for aluminum-associated anemia and to assess the prevalence of aluminum-associated anemia in an outpatient dialysis population. Both random plasma aluminum and RBC aluminum correlated well with the increase in plasma aluminum seen following DFO challenge. However, RBC aluminum was affected less by changes in oral aluminum intake than plasma aluminum. There were strong correlations of RBC and plasma aluminum to corpuscular volume (MCV) in our patients. Moreover, patients within the highest quartile of RBC aluminum had a lower mean MCV (82.1 +/- 1.7 vs 89.6 +/- 1.7, p less than .01) and hematocrit (HCT) (24.3 +/- 4 vs 28.2 +/- 1.5, p less than .05) than those within the lowest quartile. These data suggest that aluminum toxicity is an important cause of microcytic anemia in outpatient hemodialysis patients. Prospective long-term studies are needed to further define the usefulness of RBC aluminum in diagnosing and following hemodialysis patients with aluminum-induced anemia.
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慢性肾功能衰竭的贫血。
影响因子：
3.3
作者：
Anagnostou,A;Kurtzman,NA
通讯作者：
Kurtzman,NA
使用去铁胺输注试验诊断铝相关骨营养不良。
影响因子：
39.2
作者：
Milliner,DS;Nebeker,HG;Ott,SM;Andress,DL;Sherrard,DJ;Alfrey,AC;Slatopolsky,EA;Coburn,JW
通讯作者：
Coburn,JW
诊断铝骨病的间接方法：血浆铝、去铁胺输注试验和血清 iPTH。
DOI：
--
发表时间：
1986
期刊：
Kidney international. Supplement
影响因子：
--
作者：
Nebeker,HG;Andress,DL;Milliner,DS;Ott,SM;Alfrey,AC;Slatopolsky,EA;Sherrard,DJ;Coburn,JW
通讯作者：
Coburn,JW
正常和尿毒症大鼠腹腔内铝继发的小细胞性贫血。
影响因子：
19.6
作者：
Kaiser,L;Schwartz,KA;Burnatowska-Hledin,MA;Mayor,GH
通讯作者：
Mayor,GH