Making the Case for Autophagy Inhibition as a Therapeutic Strategy in Combination with Androgen-Targeted Therapies in Prostate Cancer.
Making the Case for Autophagy Inhibition as a Therapeutic Strategy in Combination with Androgen-Targeted Therapies in Prostate Cancer.
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DOI：
10.3390/cancers15205029
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发表时间：
2023-10-18
期刊：
影响因子：
5.2
通讯作者：
Gewirtz, David A.
中科院分区：
文献类型：
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作者：
Elshazly, Ahmed M.;Gewirtz, David A.
这篇文章是研究不同化疗方式诱导的肿瘤细胞自噬的功能形式的系列文章之一，主要目的是确定自噬靶向或调节是否可以作为一种有效的辅助治疗。在这篇综述中，我们重点介绍前列腺癌的雄激素靶向治疗，包括雄激素生物合成抑制剂和雄激素受体拮抗剂。雄激素受体靶向仍然是前列腺癌的主要治疗策略，包括雄激素生物合成抑制剂和雄激素受体拮抗剂。虽然雄激素受体阳性的前列腺癌和去势抵抗的前列腺癌对这些方法都有反应，但耐药性的发展几乎是不可避免的结果，导致这种疾病的去势抵抗形式。鉴于“细胞保护性”自噬在癌症文献中被认为是抵抗各种化疗药物和辐射的主要机制，本综述的目的是评估自噬是否在限制雄激素剥夺疗法在前列腺癌中的应用中发挥核心作用。与我们之前的大多数报告不同，我们发现了多种功能形式的自噬，这使得提出抑制自噬作为一种治疗策略即使不是不可能也是困难的，而在雄激素剥夺疗法中，自噬的细胞保护性形式似乎占主导地位。一旦有效和可靠的药理自噬抑制剂被开发出来，这就为改善前列腺癌患者的预后开辟了一条潜在的途径。
This paper is one in a series of articles that investigate the functional forms of autophagy induced in tumor cells in response to various chemotherapeutic modalities, with the overarching goal of determining whether autophagy targeting or modulation could serve as an effective adjuvant therapy. In this review, we focus on androgen-targeted therapies in prostate cancer, including androgen biosynthesis inhibitors and androgen receptor antagonists. Androgen receptor targeting remains the primary therapeutic strategy in prostate cancer, encompassing androgen biosynthesis inhibitors and androgen receptor antagonists. While both androgen-receptor-positive and “castration-resistant” prostate cancer are responsive to these approaches, the development of resistance is an almost inevitable outcome leading to the castration-resistant form of the disease. Given that “cytoprotective” autophagy is considered to be a predominant mechanism of resistance to various chemotherapeutic agents as well as to radiation in the cancer literature, the purpose of this review is to evaluate whether autophagy plays a central role in limiting the utility of androgen deprivation therapies in prostate cancer. Unlike most of our previous reports, where multiple functional forms of autophagy were identified, making it difficult if not impossible to propose autophagy inhibition as a therapeutic strategy, the cytoprotective form of autophagy appears to predominate in the case of androgen deprivation therapies. This opens a potential pathway for improving the outcomes for prostate cancer patients once effective and reliable pharmacological autophagy inhibitors have been developed.
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影响因子：
82.9
作者：
Chen, CD;Welsbie, DS;Sawyers, CL
通讯作者：
Sawyers, CL
DOI：
10.1158/1078-0432.ccr-08-0979
发表时间：
2008-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dagvadorj A;Tan SH;Liao Z;Cavalli LR;Haddad BR;Nevalainen MT
通讯作者：
Nevalainen MT
影响因子：
2.2
作者：
Denisenko TV;Gogvadze V;Zhivotovsky B
通讯作者：
Zhivotovsky B
影响因子：
4.8
作者：
Askew, Emily B.;Gampe, Robert T., Jr.;Wilson, Elizabeth M.
通讯作者：
Wilson, Elizabeth M.
影响因子：
5.6
作者：
通讯作者：
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