Integrin expression in cutaneous malignant melanoma: Association of the α3/β1 heterodimer with tumor progression
Integrin expression in cutaneous malignant melanoma: Association of the α3/β1 heterodimer with tumor progression
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皮肤恶性黑色素瘤中的整合素表达：α3/β1 异二聚体与肿瘤进展的关联
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
M. Nicotra
中科院分区：
文献类型：
--
作者：
P. Natali;A. Bartolazzi;R. Cavaliere;A. Bigotti;M. Nicotra
介导细胞-细胞和细胞-基质相互作用的整联蛋白分子家族的细胞表面异二聚体可能在局部和转移性肿瘤生长中具有功能相关性。在本研究中，我们分析了在皮肤恶性黑色素瘤（CMM）的肿瘤进展过程中，胶原、层粘连蛋白和纤连蛋白的α3/β1受体的表达是否发生变化。本研究的结果表明，虽然在良性病变中可检测到低水平的VLA 3表达，但在原发性黑色素瘤中，异源二聚体的表达进行性增加，这与皮肤侵袭的程度相关。82%的转移灶VLA 3阳性。此外，异二聚体在多个自体转移瘤中均匀表达。VLA 3的存在与在45%的研究病例中检测到至少一种配体相关。这些发现提供了额外的证据，表明CMM中的肿瘤进展与整合素表型（包括α3/β1异源二聚体）的变化相关。
The cell‐surface heterodimers of the integrin family of molecules, which mediate cell‐cell and cell‐substratum interactions, are likely to be functionally relevant in local and metastatic tumor growth. In the present study we have analyzed whether the α3/β1 receptor for collagen, laminin and fibronectin undergoes changes in expression during tumor progression in cutaneous malignant melanoma (CMM). The results of this study have demonstrated that, while low levels of VLA3 expression are detectable in benign lesions, in primary melanomas the heterodimer undergoes progressive increase in expression which correlates with the degree of dermal invasiveness. Metastatic lesions were found VLA3 positive in 82% of cases. Furthermore, the heterodimer is homogeneously expressed in multiple autologous metastases. The presence of VLA3 correlates with detection of at least one of the ligands in 45% of the cases studied. These findings provide additional evidence that tumor progression in CMM is associated with changes in integrin phenotypes which include the α3/β1 heterodimer.
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影响因子：
11.2
作者：
S. Albelda;S. Mette;D. Elder;R. Stewart;L. Damjanovich;M. Herlyn;C. Buck
通讯作者：
S. Albelda;S. Mette;D. Elder;R. Stewart;L. Damjanovich;M. Herlyn;C. Buck
DOI：
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发表时间：
1989-12
期刊：
Cancer cells
影响因子：
--
作者：
Erkki I. Ruoslahti;F. Giancotti
通讯作者：
Erkki I. Ruoslahti;F. Giancotti
DOI：
10.1093/jnci/82.19.1566
发表时间：
1990-10
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
G. Wolf;T. Carey;S. Schmaltz;K. Mcclatchey;J. Poore;Lynda Glaser;D. Hayashida;Sandra Hsu
通讯作者：
G. Wolf;T. Carey;S. Schmaltz;K. Mcclatchey;J. Poore;Lynda Glaser;D. Hayashida;Sandra Hsu
原发性和转移性黑色素瘤病变中细胞间粘附分子1的差异表达。
影响因子：
11.2
作者：
Natali,P;Nicotra,MR;Cavaliere,R;Bigotti,A;Romano,G;Temponi,M;Ferrone,S
通讯作者：
Ferrone,S