Relationship Between Acuity and Contrast Sensitivity: Differences Due to Eye Disease
Relationship Between Acuity and Contrast Sensitivity: Differences Due to Eye Disease
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DOI：
10.1167/iovs.61.6.40
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发表时间：
2020-06-17
影响因子：
4.4
通讯作者：
Legge GE
中科院分区：
文献类型：
--
作者：
Xiong YZ;Kwon M;Bittner AK;Virgili G;Giacomelli G;Legge GE
视力（VA）和对比敏感度（CS）表征视觉功能的不同方面。虽然VA是常规眼科检查和临床试验中的标准测试，但CS通常不包括在内。我们通过量化和比较常见眼部病理中VA和CS这两种测量之间的关系，研究了VA和CS之间的病理特异性分离。VA和CS数据来自1113名受试者，包括白内障组（n = 450）、年龄相关性黄斑变性（AMD; n = 232）、青光眼组（n = 100）、视网膜色素变性（RP; n = 87）和正常眼健康组（n = 244）。VA和CS分别通过早期治疗糖尿病视网膜病变研究图表和Pelli-Robson图表测量。即使VA相对正常（<0.3 logMAR），四个眼部病理组相对于正常对照组也显示出定量上不同的平均CS缺陷，范围从白内障的-0.01 log单位到RP的0.23 log单位。当考虑整个VA范围时，这四组之间CS的相应缺陷明显不同，白内障最少，青光眼、AMD和RP逐渐严重。VA每损失1.0 logMAR，相应的CS缺陷范围为白内障的0.22 logCS至RP的0.97 logCS。VA和CS之间的定量关系取决于眼部病理。CS似乎提供了宝贵的补充信息，VA在早期发现的眼病，并在评估视力障碍。
Visual acuity (VA) and contrast sensitivity (CS) characterize different aspects of visual function. Whereas VA is a standard test in routine eye exams and clinical trials, CS is often not included. We investigated the pathology-specific dissociation between VA and CS by quantifying and comparing the relationship between these two measures in common ocular pathologies. VA and CS data were assembled from 1113 subjects, including groups with cataract (n = 450), age-related macular degeneration (AMD; n = 232), glaucoma (n = 100), retinitis pigmentosa (RP; n = 87), and normal ocular health (n = 244). VA and CS were measured by the Early Treatment Diabetic Retinopathy Study chart and Pelli–Robson chart, respectively. Even when VA was relatively normal (<0.3 logMAR), the four ocular pathology groups showed quantitatively different mean CS deficits relative to normal controls, ranging from –0.01 log units for cataract to 0.23 log units for RP. When the entire range of VA was considered, the corresponding deficits in CS were noticeably different across these four groups, being least for cataract and progressively more severe for glaucoma, AMD, and RP. For every 1.0 logMAR loss of VA, the corresponding deficit in CS ranged from 0.22 logCS for cataract to 0.97 logCS for RP. The quantitative relationship between VA and CS depends on the ocular pathology. CS appears to provide valuable complementary information to VA in the early detection of eye disease and when evaluating visual impairment.
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影响因子：
3.4
作者：
Bittner AK;Seger K;Salveson R;Kayser S;Morrison N;Vargas P;Mendelsohn D;Han J;Bi H;Dagnelie G;Benavente A;Ramella-Roman J
通讯作者：
Ramella-Roman J
影响因子：
1.4
作者：
BROWN, B;LOVIEKITCHIN, JE
通讯作者：
LOVIEKITCHIN, JE
影响因子：
2
作者：
Hawkins, AS;Szlyk, JP;Wilensky, JT
通讯作者：
Wilensky, JT
影响因子：
1.8
作者：
Elliott, DB;Situ, P
通讯作者：
Situ, P
影响因子：
8.1
作者：
Chan, Tiffany;Friedman, David S.;Massof, Robert
通讯作者：
Massof, Robert