Randomized controlled trial of electro-stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa.
Randomized controlled trial of electro-stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa.
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DOI：
10.1111/aos.13581
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发表时间：
2018-05
影响因子：
3.4
通讯作者：
Ramella-Roman J
中科院分区：
文献类型：
--
作者：
Bittner AK;Seger K;Salveson R;Kayser S;Morrison N;Vargas P;Mendelsohn D;Han J;Bi H;Dagnelie G;Benavente A;Ramella-Roman J
在一项电刺激治疗的随机对照试验中，我们检测了视网膜色素变性(RP)参与者的视觉功能、眼部和视网膜血流量(RBF)的变化。21名RP受试者被随机(1：1：1)分为经角膜电刺激(TES)组(每周6次半小时治疗)、电针治疗组(10次半小时治疗组)或非活性激光针刺组(假对照组)。分别于治疗前、治疗2TES后、干预结束后1周和1个月测量ETDRS视力、快速对比敏感度、Goldmann视野、AdaptDx暗视敏感度、视网膜中央动脉(CRA)血流频谱和彩色多普勒成像，以及黄斑毛细血管的RBF。与假手术对照组相比，治疗2周后，TES组(p=0.038)和电针组(p=0.001)球后CRA平均血流速度均有显著改善。在完成6次TES治疗的一周内或电针治疗后1个月内，TES和电针受试者黄斑血管的RBF分别比假手术对照组(P<；0.001)增加55%和34%(P=0.008)。当比较三个干预组时，视觉功能改善的眼睛的比例有显著差异(p=0.038)：七个TES受试者中的四个(57%)，七个电针受试者中的两个(29%)，以及七个对照组受试者中没有一个(0%)在治疗后的连续两次访问中除了典型的重测可变性外，视力有显著的改善。电刺激治疗后血流增加是一种客观的生理变化，在一些RP患者中除了视觉功能改善外，还会发生这种变化。
We examined changes in visual function, and ocular and retinal blood flow (RBF) among retinitis pigmentosa (RP) participants in a randomized controlled trial of electro-stimulation therapies. Twenty-one RP participants were randomized (1:1:1) to transcorneal electrical stimulation (TES) at 6 weekly half hour sessions, electro-acupuncture or inactive laser acupuncture (sham control) at 10 half hour sessions over 2 weeks. ETDRS visual acuity, quick contrast sensitivity function, Goldmann visual fields, AdaptDx scotopic sensitivity, spectral flow and color Doppler imaging of the central retinal artery (CRA), and RBF in macular capillaries were measured twice pre-treatment, after 2 TES sessions, within a week and a month after intervention completion. We measured a significant improvement in retrobulbar CRA mean flow velocity for both the TES (p=0.038) and electro-acupuncture groups (p=0.001) on average after 2 weeks of treatment when compared to sham controls. TES and electro-acupuncture subjects had significant 55% and 34% greater increases, respectively, in RBF in the macular vessels when compared to sham controls (p<0.001)(p=0.008) within a week of completing six TES sessions or a month after electro-acupuncture. There was a significant difference in the proportion of eyes that had improved visual function when comparing the three intervention groups (p=0.038): four of seven TES subjects (57%), two of seven electro-acupuncture subjects (29%), and none of the seven control subjects (0%) had a significant visual improvement outside of typical test-retest variability at two consecutive post-treatment visits. Increased blood flow following electro-stimulation therapies is an objective, physiological change that occurred in addition to visual function improvements in some RP patients.
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DOI：
10.2147/opth.s14573
发表时间：
2010-12-06
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Kurimoto T;Oono S;Oku H;Tagami Y;Kashimoto R;Takata M;Okamoto N;Ikeda T;Mimura O
通讯作者：
Mimura O
影响因子：
3.4
作者：
Hanif AM;Kim MK;Thomas JG;Ciavatta VT;Chrenek M;Hetling JR;Pardue MT
通讯作者：
Pardue MT
影响因子：
3.7
作者：
Morimoto T;Kanda H;Miyoshi T;Hirohara Y;Mihashi T;Kitaguchi Y;Nishida K;Fujikado T
通讯作者：
Fujikado T
影响因子：
4.4
作者：
Palkovits, Stefan;Lasta, Michael;Schmetterer, Leopold
通讯作者：
Schmetterer, Leopold
通过多体素模式分析探索与视觉相关的穴位特异性
影响因子：
2.5
作者：
Li, Linling;Qin, Wei;Tian, Jie
通讯作者：
Tian, Jie