Skeletal Muscle Fat and Its Association With Physical Function in Rheumatoid Arthritis.
Skeletal Muscle Fat and Its Association With Physical Function in Rheumatoid Arthritis.
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DOI：
10.1002/acr.23278
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发表时间：
2018-03
影响因子：
4.7
通讯作者：
Piva SR
中科院分区：
文献类型：
--
作者：
Khoja SS;Moore CG;Goodpaster BH;Delitto A;Piva SR
描述类风湿关节炎（RA）患者的骨骼肌脂肪（SMF）、肌间脂肪组织（IMAT）和皮下脂肪组织（SAT），并评估这些脂肪库与身体功能和体力活动之间的关系。RA队列的横断面分析。使用大腿中段横截面区域的计算机断层扫描成像测量SMF、IMAT和SAT。采用健康评估问卷（HAQ）和一系列基于性能的测试（包括股四头肌肌力、步态速度、重复椅子站立、爬楼梯和单腿站立）测量身体功能。使用活动监测器评估身体活动。通过多元线性回归模型评估SMF、IMAT和SAT与身体功能和活动之间的相关性，该模型调整了潜在的混杂因素，如年龄、性别、体重指数、肌肉面积和力量。纳入60例RA受试者（82%为女性，年龄59 ± 10岁，BMI：31.79 ± 7.16）。在调整后的模型中，较低的SMF与较高的步态速度、单腿站立、股四头肌力量和身体活动以及较少的残疾相关（R2Δ范围0.06 - 0.25，p <0.05）;而IMAT与身体功能或活动无关; SAT与残疾（HAQ）呈负相关（R2Δ= 0.13 p<0.05），与肌肉力量呈弱正相关。(R2Δ= 0.023，p<0.05）。与IMAT或SAT积累相反，肌肉内的脂肪浸润似乎独立地导致身体功能和活动降低。纵向研究是必要的，以确认SMF对残疾和促进RA患者健康的影响。
To characterize skeletal muscle fat (SMF), intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) in individuals with rheumatoid arthritis (RA), and assess the associations between these fat depots and physical function and physical activity. Cross-sectional analysis from an RA cohort. SMF, IMAT and SAT were measured using computed tomography imaging of the mid-thigh cross-sectional region. Physical function was measured with the Health Assessment Questionnaire (HAQ) and a battery of performance-based tests that included quadriceps muscle strength, gait speed, repeated chair-stands, stair ascend, and single leg-stance. Physical activity was assessed using an activity monitor. Associations between SMF, IMAT and SAT, and physical function and activity were assessed by multiple linear regression models adjusted for potential confounders such as age, gender, body mass index, muscle area, and strength. Sixty subjects with RA (82% female, age 59 ± 10 years, BMI: 31.79 ± 7.16) were included. In the adjusted models, lower SMF was associated with greater gait speed, single leg stance, quadriceps strength, and physical activity, and less disability (R2Δ range .06−.25, p < .05); whereas IMAT did not associate with physical function or activity; and SAT was negatively associated with disability (HAQ) (R2Δ= .13 p<0.05) and weakly but positively associated with muscle strength. (R2Δ= .023, p<0.05). Fat infiltration within the muscle seems to independently contribute to low physical function and activity in contrast to IMAT or SAT accumulation. Longitudinal studies are necessary to confirm the impact of SMF on disability and promoting health in persons with RA.
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影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
影响因子：
3.2
作者：
Almeida, Gustavo J.;Irrgang, James J.;Piva, Sara R.
通讯作者：
Piva, Sara R.
DOI：
10.1111/j.1532-5415.2006.00700.x
发表时间：
2006-05-01
影响因子：
6.3
作者：
Curb, J. David;Ceria-Ulep, Clementina D.;Chen, Randi
通讯作者：
Chen, Randi
影响因子：
3.2
作者：
Almeida, Gustavo J. M.;Wasko, Mary Chester M.;Piva, Sara R.
通讯作者：
Piva, Sara R.
影响因子：
5.5
作者：
Hanh-Hung Dao;Quan-Trung Do;Sakamoto, Junichi
通讯作者：
Sakamoto, Junichi