The promise of neuro-recovery after stroke: introduction.
The promise of neuro-recovery after stroke: introduction.
复制标题
中风后神经恢复的希望：介绍。
DOI：
10.1161/strokeaha.111.000373
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发表时间：
2013
期刊：
影响因子：
8.3
通讯作者：
Krakauer,JohnW
中科院分区：
文献类型：
--
作者：
Carmichael,SThomas;Krakauer,JohnW
The study of brain repair and behavioral recovery after stroke continues to accelerate with points of convergence between findings in humans and results in animal models of stroke. Approaches to motor recovery after stroke can be usefully broken into 3 categories: reduction in impairment with a return to more normal patterns of motor behavior; compensatory responses with the other limb or even muscles within the same limb; and use of neurally controlled prosthetics that substitute for the affected limb. The future choice of any of these approaches to neurorehabilitation is likely to depend on both the severity of the initial impairment and the time since stroke onset.Stem cells have garnered a great deal of attention because they conjure up the possibility of neural regeneration and the possible reintegration of new neurons into damaged neural circuits. However, evidence suggests that stem/progenitor transplantation in stroke is not replacing damaged brain but instead enhancing or extending the processes of endogenous brain repair after stroke. This more indirect benefit is the subject of the perspective/review submitted by Dr Sean Savitz. 1 His group has focused on bone marrow–derived mononuclear cells and how they may enhance recovery in rodent stroke models. Several studies, including his own, in rodent models have shown that intravenous or intra-arterial delivery of autologous mononuclear cells lead to reduced impairment and slower infarct maturation when given within a week of stroke. The mechanisms of these benefits are not known, but preliminary evidence suggests anti-inflammatory and neuro-protective effects, as well as effects on the endogenous repair processes of neurogenesis and angiogenesis. Dr Savitz led a study showing that harvesting autologous mononuclear cells in patients after stroke and giving them back intravenously is feasible and safe. Subsequent efficacy trials will hopefully show that the enhancement of spontaneous biological recovery demonstrated with mononuclear cells in animal models will generalize to patients after stroke.
影响因子：
8.3
作者：
Savitz SI
通讯作者：
Savitz SI