Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.
Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.
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中期血管危险因素和中年认知状况与晚期轻度认知障碍和痴呆症患病率有关：社区研究中的动脉粥样硬化风险。
DOI：
10.1016/j.jalz.2018.03.011
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Mosley TH Jr
中科院分区：
文献类型：
--
作者：
Knopman DS;Gottesman RF;Sharrett AR;Tapia AL;DavisThomas S;Windham BG;Coker L;Schneider ALC;Alonso A;Coresh J;Albert MS;Mosley TH Jr
中年血管危险因素（VRF）和中年认知功能与晚年轻度认知障碍（MCI）和痴呆（DEM）之间的相互作用尚未得到很好的理解。在社区动脉粥样硬化风险（ARIC）研究中，对45-64岁的中年人的心血管风险因素和认知进行了评估。在20-25年后的2011-2013年，所有知情同意的ARIC参与者都接受了认知和神经系统评估，并被判定为认知正常、MCI或DEM。在5995名具有完整协变量数据的参与者中，中年糖尿病、高血压、肥胖和高胆固醇血症与晚年MCI和DEM相关。当两者都在模型中时，中年VRF和中年认知功能两者都与晚年MCI或DEM相关联。晚年MCI和DEM与中年VRF和中年认知独立相关。
The interplay between midlife vascular risk factors (VRF) and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. In the Atherosclerosis Risk in Communities (ARIC) Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45–64 years. In 2011–2013, 20–25 years later, all consenting ARIC participants underwent a cognitive and neurological evaluation, and were given adjudicated diagnoses of cognitively normal, MCI or DEM. In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition was also associated with greater likelihood of late-life MCI or DEM. Both midlife VRF and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. Later life MCI and DEM were independently associated with midlife VRF and midlife cognition.
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DOI：
10.1001/jama.2017.3090
发表时间：
2017-04-11
期刊：
JAMA
影响因子：
--
作者：
Gottesman RF;Schneider AL;Zhou Y;Coresh J;Green E;Gupta N;Knopman DS;Mintz A;Rahmim A;Sharrett AR;Wagenknecht LE;Wong DF;Mosley TH
通讯作者：
Mosley TH
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
29
作者：
Gottesman, Rebecca F.;Albert, Marilyn S.;Knopman, David S.
通讯作者：
Knopman, David S.
影响因子：
105.7
作者：
Kivipelto, M;Helkala, EL;Nissien, A
通讯作者：
Nissien, A
影响因子：
14
作者：
Knopman, David S.;Mosley, Thomas H.;Coker, Laura H.
通讯作者：
Coker, Laura H.