Drug use-related stigma, safer injection norms, and hepatitis C infection among a network-based sample of young people who inject drugs.
Drug use-related stigma, safer injection norms, and hepatitis C infection among a network-based sample of young people who inject drugs.
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DOI：
10.1016/j.drugalcdep.2021.108626
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发表时间：
2021-04-01
影响因子：
4.2
通讯作者：
Boodram B
中科院分区：
文献类型：
--
作者：
Williams LD;Mackesy-Amiti ME;Latkin C;Boodram B
识别丙型肝炎（HCV）感染的风险对于了解最近郊区和农村地区注射毒品（PWID）的年轻人中HCV发病率的增加以及改进有效的HCV预防干预措施的目标非常重要。现存的许多研究都集中在个人健康行为上（例如，危险的药物注射行为）作为HCV感染的预测因子。本研究探讨了两个社会因素（物质使用相关的耻辱和注射相关的社会规范），以及这些因素之间的相互作用，作为HCV感染的预测因子。基线数据来自一项正在进行的对来自芝加哥郊区的年轻PWID（N=279;平均年龄= 30.4岁）及其注射风险网络成员的纵向研究。调整后的逻辑回归模型被用来检查物质使用相关的耻辱，更安全的注射规范，HCV感染之间的关系。尽管不太安全的注射规范和HCV感染之间存在边际双变量关联（OR=0.74; 95%CI [0.39，1.02]; p= 0.071），但显著的耻辱X规范相互作用（AOR=0.68; 95%CI [0.51，0.90]）表明，在高水平的耻辱下，HCV感染的概率很高，无论注射规范如何。研究结果表明，社会因素-特别是物质使用相关的耻辱和注射规范-是HCV感染风险的重要预测因素。这些社会因素之间的相互作用表明，仅干预改变注射规范或行为可能不足以降低高耻辱环境或高耻辱人群中HCV感染的风险。未来的研究应结合安全注射干预措施开发和评估减少耻辱的干预措施，以最大限度地降低HCV风险。
Identifying risk for hepatitis C (HCV) infection is important for understanding recent increases in HCV incidence among young people who inject drugs (PWID) in suburban and rural areas; and for refining the targeting of effective HCV preventive interventions. Much of the extant research has focused on individual health behaviors (e.g., risky drug injection behaviors) as predictors of HCV infection. The present study examines two social factors (substance use-related stigma and injection-related social norms), and the interaction between these factors, as predictors of HCV infection. Baseline data were used from an ongoing longitudinal study of young PWID (N=279; mean age = 30.4 years) from the Chicago suburbs and their injection risk network members. Adjusted logistic regression models were used to examine relationships among substance use-related stigma, safer injection norms, and HCV infection. Despite a marginal bivariate association between less safe injection norms and HCV infection (OR=0.74; 95% CI[0.39, 1.02]; p=.071), a significant stigma X norms interaction (AOR=0.68; 95% CI[0.51, 0.90]) suggested that at high levels of stigma, probability of HCV infection was high regardless of injection norms. Findings suggest that social factors – specifically, substance use-related stigma and injection norms - are important predictors of HCV infection risk. The interaction found between these social factors suggests that intervening only to change injection norms or behaviors is likely insufficient to reduce risk for HCV infection in high-stigma settings or among high-stigma populations. Future research should develop and evaluate stigma-reduction interventions in combination with safer-injection interventions in order to maximize HCV risk reduction.
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DOI：
10.1038/oby.2012.12
发表时间：
2012-05
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Fettich KC;Chen EY
通讯作者：
Chen EY
影响因子：
3.7
作者：
Eckhardt B;Winkelstein ER;Shu MA;Carden MR;McKnight C;Des Jarlais DC;Glesby MJ;Marks K;Edlin BR
通讯作者：
Edlin BR
DOI：
10.1016/j.ejon.2011.06.008
发表时间：
2012-07
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
Cataldo JK;Jahan TM;Pongquan VL
通讯作者：
Pongquan VL
影响因子：
3.3
作者：
Ironson G;Fitch C;Stuetzle R
通讯作者：
Stuetzle R
影响因子：
4.2
作者：
Latkin, Carl;Srikrishnan, Aylur K.;Yang, Cui;Johnson, Sethulakshmi;Solomon, Sunil S.;Kumar, Suresh;Celentano, David D.;Solomon, Suniti
通讯作者：
Solomon, Suniti