Lung cancer stigma, depression, and quality of life among ever and never smokers.
Lung cancer stigma, depression, and quality of life among ever and never smokers.
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DOI：
10.1016/j.ejon.2011.06.008
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Pongquan VL
中科院分区：
文献类型：
--
作者：
Cataldo JK;Jahan TM;Pongquan VL
2010年，肺癌预计将成为男性和女性癌症死亡的主要原因。由于生存率不断提高，因此评价治疗对生活质量（QOL）的影响是一项重要的结局指标。在其他疾病中，耻辱感已知对健康状况和生活质量有负面影响，并且可以进行干预。这是第一项比较肺癌污名（LCS）水平以及LCS，抑郁和生活质量之间关系的研究。共有192名自我报告诊断为肺癌的参与者在线完成了问卷调查。在LCS和抑郁（r = 0.68，p < 0.001）和QOL（r =-0.65，p < 0.001）之间发现了预期方向的强关联。在人口统计学特征或研究变量中，从未吸烟者和吸烟者之间没有发现显著差异。5个自变量的多元线性回归分析显示，总体模型解释了生活质量总方差的62.5%（F5，168 = 56.015，P < 0.001）。剔除年龄、性别和吸烟状况后，抑郁对生活质量总方差的解释率为22.5%（F4，168 = 100.661，p < 0.001）。抑郁症和LCS对QOL的变异有一定的解释作用，LCS与抑郁症的相关系数为0.629（p < 0.001），但LCS对QOL的变异有独特的解释作用，其解释作用比抑郁症、年龄、性别和吸烟状况的解释作用高2.1%（p < 0.001）。
In 2010, lung cancer is expected to be the leading cause of cancer death in both men and women. Because survival rates are increasing, an evaluation of the effects of treatment on quality of life (QOL) is an important outcome measure. In other diseases, stigma is known to have a negative impact on health status and QOL and be amenable to intervention. This is the first study to compare levels of lung cancer stigma (LCS) and relationships between LCS, depression, and QOL in ever and never smokers. A total of 192 participants with a self-report diagnosis of lung cancer completed questionnaires online. Strong associations in the expected directions, were found between LCS and depression (r = 0.68, p < 0.001) and QOL (r = −0.65, p < 0.001). No significant differences were found in demographic characteristics or study variables between ever smokers and never smokers. A simultaneous multiple regression with 5 independent variables revealed an overall model that explained 62.5% of the total variance of QOL (F5,168 = 56.015, P < 0.001). After removing age, gender, and smoking status, depression explained 22.5% of the total variance of QOL (F4,168 = 100.661, p < 0.001). It is expected that depression and LCS would share some of the explanation of the variance of QOL, the correlation between LCS and depression is 0.629 (p < 0.001), however, LCS provides a unique and significant explanation of the variance of QOL over and above that of depression, age, gender, and smoking status, by 2.1% (p < 0.001).
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