Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus.
Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus.
复制标题
DOI：
10.1038/sj.bjc.6605313
复制
发表时间：
2009-10-20
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞角蛋白(CKs)是上皮细胞特有的结构标志蛋白。然而，最近的研究表明，它们参与了癌症的进展。应用免疫组织化学方法检测210例食管鳞癌(OSCC)标本中CK18及其微丝配对CK8的表达。我们还分析了它们的表达与包括预后在内的各种临床病理参数的关系。CK18和CK8在非癌鳞状上皮中均不表达，而在正常食管腺中均有表达。CK18阳性90例(42.9%)，CK8阳性85例(40.5%)，CK18和CK8免疫组化分型符合率为82.4%。CK18的表达与低分化肿瘤、新辅助化疗的使用和晚期相关。CK18阳性肿瘤患者的预后比口腔鳞癌阴性患者差(P<；0.001)。CK8的表达也有类似的趋势。多因素分析显示PT(P=0.020)、PN数(P=0.001)和CK18表达(P=0.004)是影响预后的独立因素。在83例治疗前活检标本中，有47例(56.6%)检测到CK18的表达，并与预后相关(P=0.045)。CK18/CK8的表达与口腔鳞癌的进展有关。CK18与口腔鳞癌的预后和活检标本的稳定表达显著相关，提示CK18在口腔鳞癌治疗策略的选择中有一定的应用价值。
Cytokeratins (CKs) are structural marker proteins specific for epithelial cells. However, recent studies indicate their involvement in cancer progression. We evaluated CK18 and its filament partner, CK8 expression, by immunohistochemistry in 210 resected specimens from patients with oesophageal squamous cell carcinoma (OSCC). We also analysed the relationship between their expression and various clinicopathological parameters including prognosis. Neither CK18 nor CK8 was expressed in non-cancerous squamous epithelium whereas proper oesophageal glands expressed both CKs. Ninety (42.9%) tumours were CK18 positive and 85 (40.5%) CK8 positive, and the concordance rate for immunohistochemical classification for CK18 and CK8 was 82.4%. CK18 expression correlated with poorly differentiated tumours, use of neo-adjuvant chemotherapy, and advanced stage. Prognosis of patients with CK18-positive tumours was poorer than that of patients with negative OSCC (P<0.001). A similar trend was noted for CK8 expression. Multivariate analysis identified pT (P=0.020), pN number (P=0.001), and CK18 expression (P=0.004) as independent prognostic factors. CK18 expression in 83 pretreatment biopsy specimens was detected in 47 cases (56.6%) and also correlated with prognosis (P=0.045). CK18/CK8 expression correlated with progression of OSCC. The significant correlation with prognosis and stable expression in biopsy specimen suggest usefulness of CK18 in selection of treatment strategies for OSCC.
登录
查看更多内容
影响因子：
7.5
作者：
Chu, PGG;Weiss, LM
通讯作者：
Weiss, LM
DOI：
10.1073/pnas.90.9.4261
发表时间：
1993-05-01
影响因子：
11.1
作者：
CHU, YW;RUNYAN, RB;HENDRIX, MJC
通讯作者：
HENDRIX, MJC
影响因子：
2.5
作者：
Akita, H;Doki, Y;Imaoka, S
通讯作者：
Imaoka, S
食管癌围术期患者外周血多标志物基因及微转移特征的多点定量
影响因子：
9.7
作者：
Liu, Zhian;Jiang, Ming;Ju, Huangxian
通讯作者：
Ju, Huangxian
影响因子：
5.2
作者：
Bühler, H;Schaller, G
通讯作者：
Schaller, G