Differential Reactivation and Mutagenesis of Single- and Double-Stranded DNA Viruses in Irradiated Cells from Ataxia Telangiectasia Patients
Differential Reactivation and Mutagenesis of Single- and Double-Stranded DNA Viruses in Irradiated Cells from Ataxia Telangiectasia Patients
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共济失调毛细血管扩张症患者受辐射细胞中单链和双链 DNA 病毒的差异再激活和诱变
DOI：
10.1007/978-1-4613-0709-9_31
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发表时间：
1988
期刊：
影响因子：
3.7
通讯作者：
J. Rommelaere
中科院分区：
文献类型：
--
作者：
G. Hilgers;J. Cornelis;P. J. Abrahams;R. Schouten;A. J. Eb;J. Rommelaere
关于哺乳动物细胞中诱导基因突变所涉及的细胞和分子机制，还有很多东西需要了解。紫外线和化学物质诱导突变，在大肠杆菌中产生大量 DNA 损伤，在很大程度上取决于属于所谓的 SOS 调控网络的诱导途径。由于存在大量细菌突变体，SOS 系统已在分子、现象学和遗传水平上得到了深入研究（Walker，1984）。事实证明，噬菌体作为探针特别适用于解开 SOS 诱导的大肠杆菌中的修复和诱变过程（Defais 等，1983）。在感染前经紫外线、电离辐射或各种化学诱变剂处理的细菌中，受损噬菌体的存活率增加，这种现象称为韦格尔再激活，是 SOS 系统修复成分可诱导性的第一个证据之一。类似地，SOS 诱变首次被揭示为在 Weigle 重新激活条件下增强噬菌体突变的诱导，这种反应称为 Weigle 诱变。
Still much has to be learned about the cellular and molecular mechanisms involved in the induction of gene mutations in mammalian cells. The induction of mutations by UV-light and chemicals producing bulky DNA lesions in E.coli depends to a great extent on an inducible pathway belonging to the so-called SOS regulatory network. Thanks to numerous bacterial mutants, the SOS system has been well studied at the molecular, phenomenological and genetic levels (Walker, 1984). Bacteriophages proved particularly useful as probes to unravel repair and mutagenic processes in SOS-induced E.coli (Defais et al., 1983). The increase in the survival of damaged phages in bacteria treated with UV-light, ionizing radiation or various chemical mutagens prior to infection, a phenomenon denoted Weigle Reactivation, was among the first evidence for the inducibility of a repair component of the SOS system. Similarly, SOS mutagenesis was first revealed as an enhanced induction of phage mutations under Weigle Reactivation conditions, a response known as Weigle Mutagenesis.
哺乳动物的 SOS 系统：一个错误类比的例子。
影响因子：
2.4
作者：
Rossman,TG;Klein,CB
通讯作者：
Klein,CB
紫外线照射对小鼠成纤维细胞中细小病毒-小鼠微小病毒 DNA 复制的影响。
影响因子：
14.9
作者：
Rommelaere,J;Ward,DC
通讯作者：
Ward,DC