Emerging views of the nucleus as a cellular mechanosensor.
Emerging views of the nucleus as a cellular mechanosensor.
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DOI:
10.1038/s41556-018-0038-y
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发表时间:
2018-04
影响因子:
21.3
通讯作者:
Lammerding J
中科院分区:
文献类型:
--
作者:
Kirby TJ;Lammerding J
The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization, and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. This review discusses recent findings supporting a direct role of the nucleus in cellular mechanosensing and highlights novel tools to study nuclear mechanotransduction.
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