Emerging views of the nucleus as a cellular mechanosensor.

Emerging views of the nucleus as a cellular mechanosensor.
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DOI:
10.1038/s41556-018-0038-y
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发表时间:
2018-04
影响因子:
21.3
通讯作者:
Lammerding J
Lammerding J
中科院分区:
生物学1区
文献类型:
--
作者:
Kirby TJ;Lammerding J

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细胞响应机械力的能力对于许多生物过程至关重要。新出现的证据表明,外部机械力触发核膜结构和组成,染色质组织和基因表达的变化。然而,目前尚不清楚这些过程是否起源于细胞核或细胞质信号的下游。这篇综述讨论了最近的研究结果支持细胞核的直接作用,在细胞机械传感和突出的新工具,研究核机械转导。
The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization, and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. This review discusses recent findings supporting a direct role of the nucleus in cellular mechanosensing and highlights novel tools to study nuclear mechanotransduction.
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