Diagnosis for Latent Tuberculosis Infection: New Alternatives.

Diagnosis for Latent Tuberculosis Infection: New Alternatives.
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潜伏性结核感染的诊断:新的选择。

DOI:
10.3389/fimmu.2020.02006
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发表时间:
2020
影响因子:
7.3
通讯作者:
Torres M
Torres M
中科院分区:
医学2区
文献类型:
--
作者:
Carranza C;Pedraza-Sanchez S;de Oyarzabal-Mendez E;Torres M

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潜伏性结核感染(LTBI)是一种亚临床分枝杆菌感染的基础上定义的细胞免疫反应的分枝杆菌抗原。结核菌素皮肤试验(TST)和干扰素γ释放试验(IGRA)目前用于建立LTB的诊断。然而,TST和IGRA都不能区分活动性和潜伏性结核病。此外,这些测试不能用于预测LTBI患者是否会发展为活动性结核病(TB),或者LTBI治疗是否可以有效降低发展为活动性结核病的风险。因此,在这篇文章中,我们回顾了目前的方法和一些努力,以确定一个免疫标记,可能是有用的区分LTBI从结核病和评估的有效性LTB的治疗进展到活动性结核病的风险。
Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) and the interferon gamma release assay (IGRA) are currently used to establish the diagnosis of LTB. However, neither TST nor IGRA is useful to discriminate between active and latent tuberculosis. Moreover, these tests cannot be used to predict whether an individual with LTBI will develop active tuberculosis (TB) or whether therapy for LTBI could be effective to decrease the risk of developing active TB. Therefore, in this article, we review current approaches and some efforts to identify an immunological marker that could be useful in distinguishing LTBI from TB and in evaluating the effectiveness of treatment of LTB on the risk of progression to active TB.
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