My favorite pyruvate carboxylase.

My favorite pyruvate carboxylase.
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DOI:
10.1002/iub.332
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发表时间:
2010-07
期刊:
影响因子:
4.6
通讯作者:
Wallace, John C.
Wallace, John C.
中科院分区:
生物学3区
文献类型:
--
作者:
Wallace, John C.

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在悉尼大学完成了哺乳动物生殖的分子和细胞生物学博士学位后,我的第一个博士后任命于1965年初开始在牛津大学Hans Krebs爵士的实验室工作,在那里我很高兴与Eric Newsholme博士一起研究胎儿发育过程中的胚胎发生和糖酵解的调节。我对丙酮酸羧化酶(PC)的认识是在1966年初,当时迈克尔·斯克鲁顿回到牛津大学提交他的D。腓这篇论文是在计算机的发现者、位于俄亥俄州克利夫兰市的西储大学医学院的默顿·乌特教授的实验室里花了大量时间研究计算机之后完成的。毫不奇怪,迈克尔对PC充满了感染力的热情,并向系里举办了一次出色的研讨会。1966年底,我转到了Utter教授的小组,这是一次宝贵而愉快的经历,拓宽了我的技能,填补了我知识中的一些空白,特别是在生物物理技术方面。PC的共同发现者布鲁斯·基奇教授于1968年从澳大利亚的阿德莱德大学休假回到克利夫兰,我们很快就建立了有效而愉快的合作关系。1969年末,当我到达阿德莱德时,这种合作得到了更新,1970年我在那里获得了一个教师职位,并一直持续到布鲁斯1983年退休。
Having completed a PhD in molecular and cellular biology in mammalian reproduction at the University of Sydney, my first postdoctoral appointment began early in 1965 in the laboratory of Sir Hans Krebs at Oxford University where I had the pleasure of working with Dr Eric Newsholme on the regulation of gluconeogenesis and glycolysis during fetal development. My introduction to Pyruvate Carboxylase (PC) came early in 1966 when Michael Scrutton arrived back in Oxford to submit his D. Phil. thesis after spending a remarkably productive time working on PC in the laboratory of its discoverer, Professor Merton Utter, at Western Reserve University Medical School, Cleveland, Ohio. Not surprisingly, Michael bubbled with infectious enthusiasm about PC, and presented an outstanding seminar to the Department.In late 1966 I moved to Professor Utter’s group and had an invaluable and enjoyable experience broadening my skills and filling some of the many gaps in my knowledge, particularly in biophysical techniques. The co-discoverer of PC, Professor Bruce Keech, returned to Cleveland in 1968 on sabbatical leave from the University of Adelaide, Australia, and we soon established an effective and agreeable collaboration. This collaboration was renewed in late 1969 when I arrived in Adelaide, where I secured a Faculty position in 1970, and continued until Bruce retired in 1983.
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