No evidence of impediment by three common classes of prescription drugs to post-stroke aphasia recovery in a retrospective longitudinal sample.
No evidence of impediment by three common classes of prescription drugs to post-stroke aphasia recovery in a retrospective longitudinal sample.
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DOI：
10.1371/journal.pone.0270135
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
许多药物已被确定为中风后言语语言治疗的潜在辅助药物，但考虑哪些药物可能导致恢复不太稳健也很重要。在这里，我们研究是否中风后语言恢复有意义的阻碍胆碱能，γ-氨基丁酸能，或多巴胺能药物患者接受。80名左半球卒中患者进行了回顾性检查，以了解在急性卒中入院前、住院期间或出院时使用这三类药物中的一种是否与三种常见语言测量的恢复差异相关。虽然任何候选药物的处方都相对罕见，但各组在许多影响表现的常见因素方面都非常匹配。当年龄、教育程度和急性病变体积得到控制时，服用胆碱能、GABA能或多巴胺能药物的患者与未服用的患者之间的表现没有显著差异。那些经历了语言“良好恢复”的人（随着时间的推移，任何一种语言测量改善≥10%）对这些药物的暴露与那些恢复不良的人相似。这项工作代表了这些药物类别对中风后语言恢复的影响的第一次观察，不应被解释为解决所有潜在的问题，但这些结果确实提供了适度的保证，即这些常见的药物治疗类别，当在该人群中短期给予时，似乎对中风后语言恢复没有明显的有害影响。
A number of pharmaceuticals have been identified as potential adjuvants to speech language therapy following stroke, but it is also important to consider which pharmaceuticals may result in a less robust recovery. Here we examine whether post-stroke language recovery was meaningfully impeded by cholinergic, GABAergic, or dopaminergic medications patients received. Eighty participants with left hemisphere stroke were examined retrospectively to see whether the use of one of these three classes of medication prior to admission for acute stroke, during their inpatient stay, or at discharge was associated with differences in recovery on three common measures of language. While prescription of any of the candidate drugs was relatively uncommon, groups were very well matched for many common factors that impact performance. When age, education, and acute lesion volume were controlled, there were no significant differences in performance among those taking cholinergic, GABAergic, or dopaminergic medications and those who were not. Those who experienced a “good recovery” of language (≥10% improvement on any one language measure over time) had similar exposure to these drugs to those with a poor recovery. This work represents a first look at these drug classes with regard to their effects on the recovery of language after stroke and should not be interpreted as resolving all potential for concern, but these results do offer modest reassurance that these common classes of pharmacotherapy, when given for short periods in this population, do not appear to have marked deleterious effects on post-stroke recovery of language.
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影响因子：
2
作者：
Ali, M.;Ben Basat, A. Lifshitz;Brady, M. C.
通讯作者：
Brady, M. C.
DOI：
10.1016/j.jstrokecerebrovasdis.2010.12.009
发表时间：
2011-05-01
影响因子：
2.5
作者：
Barrett, Kevin M.;Brott, Thomas G.;Meschia, James F.
通讯作者：
Meschia, James F.
影响因子：
56.9
作者：
FEENEY, DM;GONZALEZ, A;LAW, WA
通讯作者：
LAW, WA
影响因子：
9.9
作者：
BERGMAN, PS;GREEN, M
通讯作者：
GREEN, M
DOI：
10.1097/phm.0000000000000780
发表时间：
2017-10-01
影响因子：
3
作者：
Keser, Zafer;Dehgan, Michelle Weber;Francisco, Gerard E.
通讯作者：
Francisco, Gerard E.