Alterations in genetic pathways following radiotherapy for head and neck cancer.
Alterations in genetic pathways following radiotherapy for head and neck cancer.
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DOI：
10.1002/hed.26004
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Caudell JJ
中科院分区：
文献类型：
--
作者：
Naghavi AO;Kim Y;Yang GQ;Ahmed KA;Caudell JJ
放射治疗是头颈部癌治疗中不可或缺的一部分，我们假设，与未经放射治疗的头颈部癌相比，复发性头颈部癌经放射治疗后，其基因表达和信号通路活性会发生改变。从前瞻性维护的数据库中提取患者数据。采用线性微阵列分析和监督基因集富集分析来比较RT初治和RT后复发的疾病。总共分析了157名患者，96名（61%）为RT初治，61名（39%）为RT。放射治疗后，与血管生成、蛋白质翻译机制、细胞周期调节和生长因子相关的基因上调，与Myc活性和缺氧反应相关的下调（均P <0.001）。先前照射的HNC与Wnt/B-连环蛋白途径中的19/42个基因（P = 0.045）和参与MYC靶途径的119/199个基因（P = 0.024）的下调相关。RT后手术挽救复发的患者在基因表达和Wnt/B-catenin和MYC靶通路中有显著改变。这些途径可能是潜在的目标，以防止耐药性的发展。
Radiotherapy (RT) is an integral component in the treatment of head and neck cancer (HNC).We hypothesized there would be alterations in gene-expression and pathway activity in HNC samples obtained in recurrent HNC that were previously treated with RT, when compared to RT-naïve disease. Patient data was abstracted from a prospectively maintained database. Linear-microarray analysis and supervised gene-set enrichment-analysis were employed to compare RT-naive and recurrent disease after prior-RT. A total of 157 patients were analyzed, 96 (61%) were RT-naive and 61 (39%) had RT.After radiation, there was upregulation of genes associated with angiogenesis, protein-translation-machinery, cell-cycle regulation, and growth factors, and downregulation associated with Myc activity, and hypoxic response (all P < .001).Previously irradiated HNC was associated with down-regulation in 19/42 genes in the Wnt/B-catenin-pathway (P = .045)and 119/199 genes involved in the MYC target pathway (P = .024). Patients with recurrences salvaged surgically post-RT had significant alterations in gene-expression and in Wnt/B-catenin and MYC-target pathways. These pathways may represent potential targets to prevent development of resistance to RT.
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DOI：
10.1097/ppo.0b013e318238216e
发表时间：
2011-11
期刊：
Cancer journal (Sudbury, Mass.)
影响因子：
--
作者：
Fenstermacher DA;Wenham RM;Rollison DE;Dalton WS
通讯作者：
Dalton WS
影响因子：
5.7
作者：
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Pignon, Jean-Pierre
影响因子：
4.3
作者：
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通讯作者：
Cimini A
影响因子：
12.7
作者：
Smith SJ;Tilly H;Ward JH;Macarthur DC;Lowe J;Coyle B;Grundy RG
通讯作者：
Grundy RG
DOI：
10.1186/s13014-016-0672-0
发表时间：
2016-07-26
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
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通讯作者：
Hess J