Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes.
Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes.
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DOI：
10.1038/ncomms8139
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发表时间：
2015-05-14
影响因子：
16.6
通讯作者：
Chtanova, Tatyana
中科院分区：
文献类型：
--
作者：
Hampton, Henry R.;Bailey, Jacqueline;Tomura, Michio;Brink, Robert;Chtanova, Tatyana
将神经元募集到损伤部位是抗菌反应的重要第一步。然而，关于中性粒细胞从炎症组织迁移到淋巴器官的基础和相关性知之甚少。我们建立了一个基于光转换的系统来监测被招募到发炎皮肤的中性粒细胞的命运。虽然中性粒细胞被有效地募集到微生物和无菌病变的部位，但只有当原发性病变中存在细菌时，才会发生随后的重新定位到引流淋巴结。中性粒细胞的皮肤排出通过淋巴管发生，并且依赖于CD11b和CXCR4，而不是CCR7。中性粒细胞是从发炎皮肤迁移到淋巴结的主要免疫细胞，在淋巴结中它们增强淋巴细胞增殖。此外，抑制中性粒细胞从皮肤迁移减少引流淋巴结中的T细胞增殖。因此，中性粒细胞介导初始损伤部位和次级淋巴器官之间的快速细胞通讯，并调节免疫应答。 无菌和微生物损伤都导致中性粒细胞迅速聚集到炎症部位。在这里，作者表明，只有对微生物配体有反应的中性粒细胞才能离开发炎的皮肤并迁移到引流淋巴结，在那里它们刺激淋巴细胞增殖。
Neutrophil recruitment to the site of injury is an essential first step of an anti-bacterial response. However, little is known about the basis for and relevance of neutrophil migration from inflamed tissue into lymphoid organs. We established a photoconversion-based system to monitor the fate of neutrophils recruited to inflamed skin. While neutrophils are efficiently recruited to sites of both microbial and sterile lesions, subsequent re-localization to draining lymph nodes happens only when bacteria are present in the primary lesion. Skin egress of neutrophils occurs via lymphatic vessels and is dependent on CD11b and CXCR4 but not CCR7. Neutrophils are the predominant immune cell to migrate from inflamed skin into lymph nodes where they augment lymphocyte proliferation. Furthermore, inhibition of neutrophil migration from skin reduces T-cell proliferation in draining lymph nodes. Thus neutrophils mediate rapid cellular communication between the initial injury site and secondary lymphoid organs and modulate immune responsiveness. Both sterile and microbial injuries lead to rapid neutrophil recruitment to the site of inflammation. Here the authors show that only neutrophils responding to microbial ligands leave inflamed skin and migrate to draining lymph nodes where they stimulate lymphocyte proliferation.
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感染期间淋巴结中中性粒细胞迁移的动态。
影响因子：
32.4
作者：
Chtanova, Tatyana;Schaeffer, Marie;Han, Seong-Ji;van Dooren, Giel G.;Nollmann, Marcelo;Herzmark, Paul;Chan, Shiao Wei;Satija, Harshita;Camfield, Kristin;Aaron, Holly;Striepen, Boris;Robey, Ellen A.
通讯作者：
Robey, Ellen A.
DOI：
10.1101/sqb.1992.057.01.030
发表时间：
1992-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
HYNES, RO;GEORGE, EL;YANG, JT
通讯作者：
YANG, JT
影响因子：
5.5
作者：
Buckley, Christopher D.;Ross, Ewan A.;Rainger, G. Ed
通讯作者：
Rainger, G. Ed
影响因子：
4
作者：
de Veer, Michael;Kemp, Joanna;Meeusen, Els N. T.
通讯作者：
Meeusen, Els N. T.
影响因子：
4.4
作者：
Culshaw, Shauna;Millington, Owain R.;Brewer, James M.;McInnes, Iain B.
通讯作者：
McInnes, Iain B.