Spatiotemporal expression of Zic genes during vertebrate inner ear development.
Spatiotemporal expression of Zic genes during vertebrate inner ear development.
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DOI：
10.1002/dvdy.23978
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发表时间：
2013-07
影响因子：
2.5
通讯作者：
Barald, Kate F.
中科院分区：
文献类型：
--
作者：
Chervenak, Andrew P.;Hakim, Ibrahim S.;Barald, Kate F.
内耳发育涉及到来自周围组织的信号，包括邻近的后脑、骨膜间充质和脊索。这些信号包括来自后脑的SHH、FGFs、BMPs和WNTs以及来自脊索的SHH。ZIC基因在背侧神经管中表达，并在神经发育过程中发挥作用，已被认为是这些途径的效应者。这份报告根据Zic基因的表达模式检验了Zic基因参与内耳发育是否是一个站得住脚的假说。在雏鸡和小鼠发育中的内耳中，Zic基因均在背侧神经管和骨膜间充质中表达，但在耳上皮中未见表达。不同Zic基因的表达开始不同；在耳廓上皮周围的任何给定区域，多个Zic基因在同一时间在同一位置表达。ZIC基因在发育中的内耳区域的表达在小鼠和鸡中是相似的。在耳囊形成过程中，Zic表达结构域与WNT和SHH信号位点重叠，提示Zic基因在这些途径的信号调节中发挥作用。
Inner ear development involves signaling from surrounding tissues, including the adjacent hindbrain, periotic mesenchyme and notochord. These signals include SHH, FGFs, BMPs and WNTs from the hindbrain and SHH from the notochord. Zic genes, which are expressed in the dorsal neural tube and act during neural development, have been implicated as effectors of these pathways. This report examines whether Zic genes’ involvement in inner ear development is a tenable hypothesis based on their expression patterns. In the developing inner ear of both the chick and mouse, all of the Zic genes were expressed in the dorsal neural tube and variably in the periotic mesenchyme, but expression of the Zic genes in the otic epithelium was not found. The onset of expression differed among the Zic genes; within any given region surrounding the otic epithelium, multiple Zic genes were expressed in the same place at the same time. Zic gene expression in the region of the developing inner ear is similar between mouse and chick. Zic expression domains overlap with sites of WNT and SHH signaling during otocyst patterning, suggesting a role for Zic genes in modulating signaling from these pathways.
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DOI：
10.1023/a:1007057719025
发表时间：
1999-10-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Hutson, MR;Lewis, JE;Barald, KF
通讯作者：
Barald, KF
影响因子：
2.7
作者：
Liang, Jennifer K.;Bok, Jinwoong;Wu, Doris K.
通讯作者：
Wu, Doris K.
DOI：
10.1007/s10162-008-0110-6
发表时间：
2008-03-01
影响因子：
2.4
作者：
Braunstein, Evan M.;Crenshaw, E. Bryan, III;Adams, Joe C.
通讯作者：
Adams, Joe C.
影响因子：
2.7
作者：
Elms, P;Siggers, P;Arkell, R
通讯作者：
Arkell, R
影响因子：
2.7
作者：
Fujimi, Takahiko J.;Hatayama, Minoru;Aruga, Jun
通讯作者：
Aruga, Jun