Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: a randomized controlled single-blind trial.
Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: a randomized controlled single-blind trial.
复制标题
针刺与安慰剂针刺在 P6 时作为大剂量化疗和自体外周血干细胞移植中额外止吐预防的效果相比：一项随机对照单盲试验。
作者：
K. Streitberger;M. Friedrich;H. Bardenheuer;K. Unnebrink;J. Windeler;H. Goldschmidt;G. Egerer
目的
目的是研究在接受大剂量化疗和自体外周血干细胞移植的患者中，与非皮肤穿透安慰剂针刺相比，在P6针刺昂丹司琼的额外止吐效果。
实验设计
80例住院接受大剂量化疗和自体外周血干细胞移植的患者被纳入一项随机安慰剂对照单盲试验。患者随机接受针刺（n = 41）或非侵入性安慰剂针刺（n = 39）在穴位P6首次应用大剂量化疗前30分钟和第二天。所有患者均接受8 mg昂丹司琼/天静脉注射作为基本止吐预防。主要结果指标是在化疗的前2天至少有一次呕吐或需要任何额外止吐药物的患者的比率。
结果
主要结果测量显示无显著差异（P = 0.82）：针灸组61%失败，安慰剂针灸组64%（3%差异的95%置信区间：-18.1和24.3%）。比较恶心、呕吐或干呕发作和额外需要的止吐药物数量与主要结果没有任何差异。
结论
这项研究表明，与昂丹司琼静脉注射相结合，与非皮肤穿透安慰剂针刺相比，P6的侵入性针刺对预防高剂量化疗中的急性恶心和呕吐没有额外的效果。
PURPOSE
The purpose is to investigate an additional antiemetic effect to ondansetron with needle acupuncture at P6 compared with nonskin-penetrating placebo acupuncture in patients undergoing high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
EXPERIMENTAL DESIGN
Eighty patients who were admitted to hospital for high-dose chemotherapy and autologous peripheral blood stem cell transplantation were included into a randomized placebo-controlled single-blind trial. The patients were randomized to receive acupuncture (n = 41) or noninvasive placebo acupuncture (n = 39) at the acupuncture point P6 30 min before first application of high-dose chemotherapy and the day after. All patients received 8 mg ondansetron/day i.v. as basic antiemetic prophylaxis. The main outcome measure was the rate of patients who either had at least one episode of vomiting or required any additional antiemetic drugs on the first 2 days of chemotherapy.
RESULTS
The main outcome measure showed no significant difference (P = 0.82): 61% failure in the acupuncture group and 64% in the placebo acupuncture group (95% confidence interval of 3% difference: -18.1 and 24.3%). Comparing nausea, episodes of vomiting or retching and number of additionally required antiemetic drugs did not provide any discrepancy with the main result.
CONCLUSIONS
This study suggests that in combination with ondansetron i.v., invasive needle acupuncture at P6 compared with nonskin-penetrating placebo acupuncture has no additional effect for the prevention of acute nausea and vomiting in high-dose chemotherapy.
常规剂量化疗与高剂量化疗联合自体造血干细胞移植治疗转移性乳腺癌的经济分析。
DOI：
10.1038/sj.bmt.1703795
发表时间：
2003
期刊：
Bone marrow transplantation.
影响因子：
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作者：
Schulman,KA;Stadtmauer,EA;Reed,SD;Glick,HA;Goldstein,LJ;Pines,JM;Jackman,JA;Suzuki,S;Styler,MJ;Crilley,PA;Klumpp,TR;Mangan,KF;Glick,JH
通讯作者：
Glick,JH