Ethnic differences in mammographic densities: an Asian cross-sectional study.
Ethnic differences in mammographic densities: an Asian cross-sectional study.
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乳房X线照相密度的种族差异：亚洲横断面研究。
DOI：
10.1371/journal.pone.0117568
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Teo SH
中科院分区：
文献类型：
--
作者：
Mariapun S;Li J;Yip CH;Taib NA;Teo SH
乳腺密度是乳腺癌的一个强有力的风险因素，并且具有高度可变性，但迄今为止，很少有研究检查亚洲妇女的密度，特别是在遗传和生活方式决定因素可能显着不同的低收入和中等收入亚洲国家。共有1 240名参加机会性乳房X光检查方案的妇女有资格接受分析。使用全自动阈值法估计乳腺摄影密度，并使用线性回归法检查205名随机选择的中国女性、138名马来女性和199名印度女性的种族差异。中国女性的密度百分比显著高于（28.5%; 95% CI 27.0%，30.0%）与马来人相比（24.2%; 95% CI 22.5%，26.0%）和印度人（24.3%; 95% CI 22.8%，25.7%）女性（p<0.001），调整年龄、BMI、绝经状态、产次和首次足月妊娠时的年龄后。相应地，中国人校正的非致密区显著较低（72.2cm2; 95% CI 67.9cm2，76.5cm2）女性与马来人相比（92.1cm2; 95% CI 86.9cm2，97.2cm2）和印度人（97.7 cm 2; 95% CI 93.4 cm 2，101.9 cm 2）女性（p<0.001），但致密面积在三个种族组之间没有差异。我们的研究表明，较高的密度百分比和较低的非密度区域反映了马来西亚华人女性乳腺癌的发病率高于马来人和印度女性。已知的乳腺摄影密度的生活方式决定因素不能完全解释在这个亚洲队列中观察到的乳腺摄影密度的种族差异。
Mammographic density is a strong risk factor for breast cancer and is highly variable, but, to date, few studies have examined density in Asian women, particularly those in low and middle-income Asian countries where genetic and lifestyle determinants may be significantly different. A total of 1,240 women who attended an opportunistic mammogram screening programme were eligible for analysis. Mammographic density was estimated using a fully-automated thresholding method and differences across ethnic groups were examined using linear regression in 205 randomly selected Chinese women, 138 Malay and 199 Indian women. Percent density was significantly higher in Chinese women (28.5%; 95% CI 27.0%, 30.0%) compared to Malay (24.2%; 95% CI 22.5%, 26.0%) and Indian (24.3%; 95% CI 22.8%, 25.7%) women (p<0.001), after adjustment for age, BMI, menopausal status, parity and age at first full term pregnancy. Correspondingly, adjusted nondense area was significantly lower in Chinese (72.2cm2; 95% CI 67.9cm2, 76.5cm2) women compared to Malay (92.1cm2; 95% CI 86.9cm2, 97.2cm2) and Indian (97.7cm2; 95% CI 93.4cm2, 101.9cm2) women (p<0.001), but dense area did not differ across the three ethnic groups. Our study shows that higher percent density and lower nondense area reflect the higher incidence of breast cancer in Chinese compared to Malay and Indian women in Malaysia. Known lifestyle determinants of mammographic density do not fully account for the ethnic variations observed in mammographic density in this Asian cohort.
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影响因子：
3.8
作者：
Maskarinec, Gertraud;Pagano, Ian;Gram, Inger Torhild
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
--
作者：
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通讯作者：
Yu MC
影响因子：
45.3
作者：
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通讯作者：
Holmberg, L