Estrogen is involved in improvement of impaired cardiac glucose uptake in cancer patients.
Estrogen is involved in improvement of impaired cardiac glucose uptake in cancer patients.
复制标题
雌激素参与改善癌症患者心脏葡萄糖摄取受损的情况。
DOI：
10.1016/j.jccase.2012.09.009
复制
发表时间：
2013
影响因子：
--
通讯作者：
Y. Kumon
中科院分区：
文献类型：
--
作者：
Y. Kakinuma;S. Okada;N. Ikenoue;M. Nogami;Y. Kumon
我们以前证明，炎症应激损害心脏葡萄糖摄取，使用氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）显示，与正常受试者相比，一个比例的患者与微妙的FDG信号显着增加。本研究评估了癌症相关应激对女性癌症患者心脏葡萄糖摄取的抑制作用，并将结果与健康女性受试者的结果进行了比较。女性癌症患者的心脏葡萄糖摄取量降低，表现为FDG摄取量低的患者数量显著高于FDG摄取量低和FDG摄取量高的健康受试者数量。这些结果表明，癌症相关的压力抑制心脏葡萄糖的利用。从78例女性癌症患者中，13例卵巢切除患者在接受雌激素衍生物激素替代治疗（HRT）前后接受FDG-PET/CT重复术后随访检查，以确定雌激素对心脏葡萄糖摄取的影响。HRT使FDG信号高的患者比例增加到与FDG摄取高的健康受试者相当，而FDG摄取差的患者比例下降。这些结果表明，雌激素可以改善心脏葡萄糖摄取的癌症切除和卵巢切除患者。
We previously demonstrated that inflammatory stress impaired cardiac glucose uptake, using fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) by showing that a proportion of patients with subtle FDG signals was remarkably increased compared with that of normal subjects. The current study assessed the inhibitory effects of cancer-associated stress on cardiac glucose uptake in female cancer patients, and compared the results with those obtained for healthy female subjects. Cardiac glucose uptake was decreased in female cancer, as indicated by the significantly higher number of patients with poor FDG uptake and the lower number of patients with high FDG uptake, compared with the number of healthy subjects with poor and high FDG uptake, respectively. These results suggest that cancer-associated stress inhibited cardiac glucose utilization. From the 78 female cancer patients, 13 oophorectomized patients, who underwent repeated postoperative follow-up examinations by FDG-PET/CT before and after receiving hormone replacement therapy (HRT) with estrogen derivatives, were analyzed to determine the effects of estrogen on cardiac glucose uptake. HRT increased a proportion of patients with high FDG signals to comparable in healthy subjects with high FDG uptake, whereas that of patients with poor FDG uptake decreased. These results suggest that estrogen can improve cardiac glucose uptake in cancer-resected and oophorectomized patients.
影响因子：
3.3
作者：
Ueyama, Takashi;Ishikura, Fuminobu;Beppu, Shintaro
通讯作者：
Beppu, Shintaro