Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis
Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis
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人参通过增强细胞介导的免疫和维持氧化还原稳态来化学预防皮肤癌的发生和促进
DOI：
10.1016/j.jgr.2019.05.004
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发表时间：
2019-05
影响因子：
6.3
通讯作者：
Lu Yin
中科院分区：
文献类型：
--
作者：
Yu Suyun;Wang Siliang;Huang Shuai;Wang Wei;Wei Zhonghong;Ding Yushi;Wang Aiyun;Huang Shile;Chen Wenxing;Lu Yin
背景人参（Radix et Rhizoma Ginseng，以下简称人参）作为一种药用植物，几千年来一直被用于维持人们的身体活力，并且在一些流行病学和临床前研究中也是一种非器官特异性癌症预防和治疗的传统药物。人参毒副作用小，对机体免疫力有较强的增强作用，在癌症化学预防中具有很好的应用潜力和价值。方法采用7，12-二甲基苯并[a]蒽/12-O-十四酰佛波醇-13-乙酸酯诱发小鼠皮肤癌模型，观察人参对小鼠皮肤癌的化学预防作用。采用超高效液相色谱/质谱联用技术对人参中的主要活性成分人参皂苷进行了定性分析。综合方法（包括网络药理学，生物信息学，实验验证）被用来探索潜在的目标，人参。ResultsGinseng治疗抑制皮肤癌的启动和促进。Rb 1、Rb 2、Rc和Rd皂苷在小鼠血液和皮肤组织中的含量最高。人参及其活性成分能很好地维持模型的氧化还原稳态，调节免疫反应。人参治疗通过上调HSP 27的表达增强T细胞介导的免疫应答抑制皮肤癌的发生，通过促进Nrf 2的核转位维持细胞内氧化还原平衡抑制皮肤癌的发生。人参可以作为一种化学预防剂潜在地用于皮肤癌，介导的免疫和维持氧化还原稳态与多个组件，目标和链接。
BackgroundRadix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non–organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms.MethodsThe mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng.ResultsGinseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cell–mediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2.ConclusionAccording to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.
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DOI：
10.4049/jimmunol.1402804
发表时间：
2015-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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影响因子：
11.4
作者：
Meng, Jiao;Lv, Zhenyu;Qiao, Xinhua;Li, Xiaopeng;Li, Yazi;Zhang, Yuying;Chen, Chang
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DOI：
10.1196/annals.1397.059
发表时间：
2007-01-01
期刊：
SIGNAL TRANSDUCTION PATHWAYS, PT C
影响因子：
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作者：
Park, Sin-Aye;Kim, Eun-Hee;Surh, Young-Joon
通讯作者：
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影响因子：
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作者：
Sporn, MB;Suh, N
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