Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases.

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases.
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不同类型胃肠道疾病患者致病性幽门螺杆菌基因多态性分析

DOI:
10.3748/wjg.v22.i44.9718
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发表时间:
2016-11-28
影响因子:
4.3
通讯作者:
Liang Q
Liang Q
中科院分区:
医学2区
文献类型:
--
作者:
Chen YL;Mo XQ;Huang GR;Huang YQ;Xiao J;Zhao LJ;Wei HY;Liang Q

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幽门螺杆菌(Helicobacter pylori, H. pylori)是一种慢性感染性病原体,可引起慢性胃炎、消化性溃疡、胃癌等疾病。幽门螺杆菌致病基因的遗传结构差异很大,这导致了不同菌株之间毒力的差异,以及临床症状的差异。幽门螺杆菌的毒力基因主要分为三类:与粘附和定植有关的基因、与胃粘膜损伤有关的基因和其他基因。本文就三类幽门螺杆菌毒力基因的遗传多态性与疾病的关系作一综述。本文综述了幽门螺杆菌主要毒力因子的大部分遗传多态性。
Helicobacter pylori (H. pylori) is a kind of chronic infectious pathogen which can cause chronic gastritis, peptic ulcer, gastric cancer and other diseases. The genetic structure of the pathogenic genes of H. pylori varies largely, which contributes to the differences in virulence among various strains, and in clinical symptoms. Virulence genes of H. pylori can be categorized into three main classes: those related to adhesion and colonization, those related to gastric mucosal injury, and others. This review focuses on the relationship between genetic polymorphisms of the three classes of virulence genes of H. pylori and diseases. Most of the genetic polymorphisms of the main virulence factors of H. pylori are summarized in this paper.
DOI: 10.1099/mic.0.2007/016055-0
发表时间: 2008-08
期刊: Microbiology (Reading, England)
影响因子: --
作者:
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